评估超声洁治器与盐酸米诺环素联合治疗糖尿病性牙周炎的有效性与安全性  

Evaluate the Effectiveness and Safety of the Combination of Ultrasonic Scaler and Minocycline Hydrochloride in the Treatment of Diabetic Periodontitis

作　　者：向辉辉 王辉艳 宋帅 XIANG Huihui;WANG Huiyan;SONG Shuai(Xingshan County People's Hospital,Yichang 443700,Hubei,China)

机构地区：[1]湖北省宜昌市兴山县人民医院,湖北宜昌443700

出　　处：《糖尿病新世界》2024年第18期192-195,共4页Diabetes New World

摘　　要：目的评估超声洁治器与盐酸米诺环素联合治疗糖尿病性牙周炎的有效性与安全性。方法选取2023年1月—2024年6月湖北省宜昌市兴山县人民医院收治的80例糖尿病性牙周炎患者为研究对象,根据不同的治疗方式分为对照组和探究组,每组40例。对照组接受常规血糖控制联合超声洁治器治疗,探究组在对照组基础上联合盐酸米诺环素治疗。对比两组牙周状况、炎性因子水平及并发症发生率。结果治疗后,探究组探诊深度、牙周袋深度、探诊出血指数、菌斑指数均低于对照组,差异有统计学意义(P均<0.05)。治疗后,探究组血清C反应蛋白、肿瘤坏死因子-α、白细胞介素-6、基质金属蛋白酶-8水平均低于对照组,差异有统计学意义(P均<0.05)。探究组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论超声洁治器与盐酸米诺环素联合治疗糖尿病性牙周炎相较于常规血糖控制联合超声洁治器治疗,能够更有效地改善患者的牙周情况,降低炎性因子水平,且安全性更高。Objective To evaluate the effectiveness and safety of the combination of ultrasonic scaler and minocycline hydrochloride in the treatment of diabetic periodontitis.Methods A total of 80 patients with diabetic periodontitis admitted to Xingshan County People's Hospital from January 2023 to June 2024 were selected as the research objects.According to different treatment methods,they were divided into control group and study group,with 40 cases in each group.The control group was treated with conventional blood glucose control combined with ultrasonic scaling,while the study group was treated with minocycline hydrochloride on the basis of the control group.The periodontal status,levels of inflammatory factors and incidence of complications were compared between the two groups.Results After treatment,the probing depth,periodontal pocket depth,bleeding index,plaque index in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of serum C-reactive protein,tumor necrosis factor-α,interleukin-6,matrix metalloproteinase-8 in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The incidence of complications in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of ultrasonic scaler and minocycline hydrochloride for the treatment of diabetic periodontitis can improve the periodontal condition of patients more effectively,reduce the level of inflammatory factors,and have a higher safety compared with the treatment of conventional glycaemic control combined with ultrasonic scaler.

关 键 词：超声洁治器 盐酸米诺环素 糖尿病性牙周炎 有效性 安全性 

分 类 号：R587.1[医药卫生—内分泌] R781.42[医药卫生—内科学]