自血穴位注射治疗慢性阻塞性肺疾病的Meta分析  

A Meta-analysis of treating chronic obstructive pulmonary disease by self-blood acupoint injection

作　　者：王珊珊[1] 蔡成森[2] 于健健 司雪杰 王珺[2] 陈文靖[2] WANG Shanshan

机构地区：[1]山东中医药大学,山东济南250014 [2]山东中医药大学第二附属医院,山东济南250001

出　　处：《中医临床研究》2024年第29期114-123,共10页Clinical Journal Of Chinese Medicine

基　　金：山东省中医药科技青年基金项目(2021Q101);山东省中医药科技青年项目(Q-2023041)。

摘　　要：目的:评价自血穴位注射治疗慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease,COPD)的临床有效性。方法:检索中国知网、PubMed等数据库从建库至2023年10月8日的自血穴位注射治疗COPD的临床随机对照试验研究,由两位研究人员分别对文献进行筛选,提取数据,并对入选的文献进行偏倚风险评估,然后使用RevMan 5.4进行Meta分析。结果:共纳入22个随机对照试验研究,共计1881例患者。Meta分析结果显示:与对照组相比,加用自血疗法能提高临床总有效率[OR=3.73,95%CI(2.79,4.98),P<0.00001],延长6 min步行试验(6-minute Walk Test,6 WMT)[MD=34.21,95%CI(24.92,43.51),P<0.00001],改善慢性阻塞性肺疾病评估测试(COPD Assessment Test,CAT)评分[MD=-3.86,95%CI(-5.20,-1.26),P<0.00001],提高肺功能指标如用力肺活量(Forced Vital Capacity,FVC)[MD=0.45,95%CI(0.42,0.49),P<0.00001]等19个结局指标,组间差异具有统计学意义。结论:自血疗法治疗COPD可显著提高临床有效率,改善6 WMT,降低中医证候积分、圣乔治呼吸问题问卷(St.George's Respiratory Questionnaire,SGRQ)评分、CAT评分等,改善肺功能,减少炎症指标,提高患者的免疫功能和生活质量。Objective:To evaluate the clinical effectiveness of self-blood acupoint injection in the treatment of chronic obstructive pulmonary disease(COPD).Methods:Databases such as China Knowledge and Pubmed were searched to retrieve studies on the clinical randomized controlled trials of treating COPD by self-blood acupoint injections from the establishment of the databases to October 8,2023.Two researchers severally screened the literature,extracted the data,and assessed the risk of bias for the selected ones,and then performed a Meta-analysis by RevMan 5.4.Results:A total of 22 studies with 1881 patients were included in the study,and the results of the Meta-analysis showed that compared with the control group,self-blood acupoint injection increased the total clinical efficiency[OR=3.73,95%CI(2.79,4.98),P<0.00001]and prolonged 6 WMT distances[MD=34.21,95%CI(24.92,43.51),P<0.00001],ameliorated CAT score[MD=-3.86,95%CI(-5.20,-1.26),P<0.00001],and improved lung function indexes such as FVC[MD=0.45,95%CI(0.42,0.49),P<0.00001],a total of 19 outcome indexes,and the differences were statistically significant between groups.Conclusions:Self-blood acupoint injection in the treatment of COPD can significantly improve 6 WMT distances,decrease TCM syndrome scores,SGRQ score and CAT score,improve the lung function,reduce the inflammatory index levels,and improve the immune function and the quality of life of the patients.

关 键 词：慢性阻塞性肺疾病 自血穴位注射 META分析 

分 类 号：R256.1[医药卫生—中医内科学]