健脾理气汤灌肠联合温针灸对胃癌根治术后患者胃肠激素、营养状况及免疫功能影响  

Effects of enema with the Jianpi Liqi decoction plus warm acupuncture on gastrointestinal hormones,nutritional status and immune function in patients after radical gastrectomy for gastric cancer

作　　者：张仑 闵振兴 刘洪涛 ZHANG Lun

机构地区：[1]北京市宣武中医医院,北京100050

出　　处：《中医临床研究》2024年第29期140-145,共6页Clinical Journal Of Chinese Medicine

摘　　要：目的:研究健脾理气汤灌肠联合温针灸对胃癌根治术后患者胃肠激素、营养状况及免疫功能的影响。方法:回顾性分析2021年2月-2023年3月北京市宣武中医医院收治的126例胃癌根治术患者的临床资料,根据治疗方法不同分为联合组(50例)、针灸组(40例)和常规组(36例)。常规组患者接受盐酸甲氧氯普胺注射液肌肉注射治疗,针灸组在常规组基础上增加温针灸治疗,联合组在常规组基础上增加健脾理气汤灌肠联合温针灸治疗。三组疗程均为2周。比较治疗后三组患者的临床疗效、治疗前后胃肠激素[胃动素(Motilin,MTL)、胃泌素(Gastrin,GAS)及生长抑素(Somatostatin,SS)]水平、中医证候积分、免疫功能指标[免疫球蛋白(Immunoglobulin,Ig)A、IgG、IgM]水平。结果:治疗后,联合组总有效率达到92.00%(46/50),针灸组总有效率为85.00%(34/40),常规组仅75.00%(27/36),联合组疗效优于针灸组和常规组。治疗后,联合组MTL、GAS及SS水平明显低于针灸组和常规组(P<0.05)。联合组中医证候积分明显低于针灸组和常规组(P<0.05)。联合组IgA、IgG及IgM水平明显高于针灸组和常规组(P<0.05)。联合组血红蛋白(Hemoglobin,Hb)、前白蛋白(Prealbumin,PAB)及血浆总蛋白(Total Protein,TP)水平明显高于针灸组和常规组,转铁蛋白(Transferrin,TRF)水平明显低于针灸组和常规组(P<0.05)。三组患者不良反应发生情况比较,无显著差异(P>0.05)。结论:健脾理气汤灌肠联合温针灸可有效改善胃癌根治术后患者胃肠激素水平和营养状况,促进免疫功能恢复,且安全性好,具有较高的临床应用价值。Objective:To probe the effects of enema with the Jianpi Liqi decoction(健脾理气汤)plus warm acupuncture on gastrointestinal hormone,nutritional status and immune function in postoperative patients with gastric cancer.Methods:A retrospective analysis was made on 126 cases of gastric cancer from February 2021 to March 2023,which were divided into the combined group(50 cases),the acupuncture group(40 cases)and the routine group(36 cases).The patients in the routine group received intramuscular injection of metoclopramide dihydrochloride injection,the acupuncture group received warm acupuncture on the basis of the treatment in the routine group,and the combined group received enema with the Jianpi Liqi decoction plus warm acupuncture on the basis of the treatment in the routine group.The treatment course in the three groups was 2 weeks.The clinical effects in 3 groups were compared.Before and after the treatment,the levels of gastrointestinal hormones[motilin(MTL),gastrin(GAS)and somatostatin(SS)],TCM symptom scores,immune function indexes[immunoglobulin A(IgA)],IgG,IgM and other indicators were observed.Results:The total effective rate was 92.00%(46/50)in the combined group and 85.00%(34/40)in the acupuncture group,but only 75.00%(27/36)in the routine group.After treatment,the levels of MTL,GAS and SS in the combined group were significantly lower than the acupuncture group and the routine group(P<0.05).The combined group showed significantly lower TCM symptom scores than the acupuncture group and the routine group(P<0.05).The levels of IgA,IgG and IgM in the combined group were significantly higher than the acupuncture group and the routine group(P<0.05).The level of Hb,PAB and TP in the combined group was significantly higher than the acupuncture group and the routine group.And the level of TRF was significantly lower than the acupuncture group and the routine group(P<0.05).The adverse reactions among three goups did not show significant differences(P>0.05).Conclusion:Enema with the Jianpi Liqi decoction plus

关 键 词：健脾理气汤 温针灸 胃癌根治术 胃肠激素 免疫功能 

分 类 号：R273[医药卫生—中西医结合]