小柴胡汤治疗少阳失枢轻型复发性口腔溃疡患者的临床效果  

Xiaochaihu decoction for patients with mild recurrent oral ulcer of Shaoyang Shishu type

作　　者：刘琪亮 李碧娥[1] 邵海宾[1] 冷嫦娥 夏长普[1] 麦熙[2] Liu Qiliang;Li Bi'e;Shao Haibin;Leng Chang'e;Xia Changpu;Mai Xi(Department of Stomatology,Huadu District Maternity and Child Health Hospital(Huzhong Hospital),Huadu Hospital Affiliated to Guangdong Medical University,Guangzhou 510800,China;Department of Chinese Medical Stomatology,School and Hospital of Stomatology,Guangzhou Medical University,Guangdong Engineering Research Center of Oral Restoration and Reconstruction,Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine,Guangzhou 510182,China)

机构地区：[1]广州市花都区妇幼保健院(胡忠医院)广东医科大学花都临床医学院口腔科,广州510800 [2]广州医科大学口腔医学院·附属口腔医院口腔中医科广东省口腔组织修复与重建工程技术研究中心广州市口腔再生医学基础与应用研究重点实验室,广州510182

出　　处：《国际医药卫生导报》2024年第23期3988-3991,共4页International Medicine and Health Guidance News

基　　金：广东省中医药局科研资助项目(20221306)。

摘　　要：目的探讨小柴胡汤治疗少阳失枢轻型复发性口腔溃疡(ROU)的临床疗效。方法采用前瞻性研究,选取2023年3月至2024年2月于广州市花都区妇幼保健院就诊的少阳失枢轻型ROU患者120例作为研究对象,采用随机数字表法分为对照组(60例)和观察组(60例)。对照组男20例、女40例,年龄(41.42±0.41)岁,病程(2.53±0.26)年,采用康复新液治疗;观察组男22例、女38例,年龄(39.78±0.66)岁,病程(2.11±0.71)年,采用康复新液联合小柴胡汤治疗。对比两组疗效、治疗7 d后溃疡愈合时间、激惹疼痛持续时间、中医症状积分变化及半年内复发情况。统计学方法采用t检验、χ^(2)检验。结果观察组治疗总有效率为88.3%(53/60),高于对照组的71.7%(43/60),差异有统计学意义(χ^(2)=5.208,P=0.022)。观察组口腔溃疡激惹疼痛持续时间、溃疡愈合时间均短于对照组[(2.67±0.34)d比(4.55±0.61)d、(4.24±0.21)d比(7.68±0.87)d],差异均有统计学意义(t=20.852、29.773,均P<0.05)。治疗7 d后,观察组中医症状积分差值为(5.66±0.82)分,低于对照组的(8.41±1.21)分,差异有统计学意义(t=14.573,P<0.001)。观察组患者治疗后6个月复发率为41.67%(25/60),低于对照组的80.00%(48/60),差异有统计学意义(χ^(2)=18.502,P<0.001)。结论小柴胡汤能有效治疗少阳失枢轻型ROU患者局部及全身症状,降低复发率。Objective To assess the clinical effect of Xiaochaihu decoction in the treatment of patients with mild recurrent oral ulcer(ROU)of Shaoyang Shishu type.Methods A total of 120 patients with mild ROU of Shaoyang Shishu type treated at Huadu District Maternity and Child Health Hospital were selected for the randomized controlled trial,and were divided into a control group and an observation group by the random number table method,with 60 cases in each group.There were 20 males and 40 females in the control group;they were(41.42±0.41)years old;their disease course was(2.53±0.26)years.There were 22 males and 38 females in the observation group;they were(39.78±0.66)years old;their disease course was(2.11±0.71)years.Both groups were treated with Kangfuxin liquid;in addition,the observation group took Xiaochaihu decoction.The efficacies,ulcer healing time after 7 days'treatment,irritation pain duration,changes of the scores of traditional Chinese medicine(TCM)symptoms,and recurrence rates within six months after the treatment were compared between the two groups.t and χ^(2) tests were applied.Results The total effective rate in the observation group was higher than that in the control group[88.3%(53/60)vs.71.7%(43/60)],with a statistical difference(χ^(2)=5.208;P=0.022).The irritation pain duration and ulcer healing time in the observation group were shorter than those in the control group[(2.67±0.34)d vs.(4.55±0.61)d and(4.24±0.21)d vs.(7.68±0.87)d],with statistical differences(t=20.852 and 29.773;both P<0.05).After 7 days'treatment,the difference of TCM score in the observation group was lower than that in the control group(5.66±0.82 vs.8.41±1.21),with a statistical difference(t=14.573;P<0.001).The recurrence rate within six months after the treatment in the observation group was lower than that in the control group[41.67%(25/60)vs.80.00%(48/60)],with a statistical difference(χ^(2)=18.502;P<0.001).Conclusion Xiaochaihu decoction for patients with mild recurrent oral ulcer of Shaoyang Shishu type can relieve

关 键 词：复发性口腔溃疡 少阳失枢 小柴胡汤 临床观察 

分 类 号：R276.8[医药卫生—中医五官科学]