早发型子痫前期患者血清GDF-15、PPARγ水平与凝血指标和预后的关系  

Relationship of serum levels of GDF-15 and PPARγ with coagulation indicators and prognosis in patients with early-onset preeclampsia

作　　者：唐明波 潘永恒 兰朝阳 Tang Mingbo;Pan Yongheng;Lan Zhaoyang(Department of Blood Donation Service,Ankang Central Blood Station,Ankang 725000,China;Department of Clinical Laboratory,Ankang Central Blood Station,Ankang 725000,China;Department of Clinical Laboratory,Ankang Maternal and Child Health Hospital,Ankang 725000,China)

机构地区：[1]安康市中心血站献血服务科,安康725000 [2]安康市中心血站检验科,安康725000 [3]安康市妇幼保健院检验科,安康725000

出　　处：《国际医药卫生导报》2024年第23期3992-3996,共5页International Medicine and Health Guidance News

基　　金：陕西省重点研发计划(2022SF-102)。

摘　　要：目的探讨早发型子痫前期患者血清生长分化因子15(growth differentiation factor 15,GDF-15)、过氧化物酶体增殖物激活受体γ(peroxisome proliferator-activated receptor gamma,PPARγ)水平与凝血指标之间的关系及其对预后的影响。方法选取2020年5月至2023年5月安康市妇幼保健院收治的76例早发型子痫前期患者为研究组,另选取同期75例健康孕妇为对照组。采用酶联免疫吸附试验检测血清中GDF-15和PPARγ水平。检测两组凝血功能指标[部分活化凝血活酶时间(activated partial thromboplastin time,APTT)、凝血酶时间(thrombin time,TT)、凝血酶原时间(prothrombin time,PT)、纤维蛋白原(fibrinogen,FIB)]。对患者预后情况进行随访。GDF-15和PPARγ水平与凝血功能的关系采用Pearson积差系数进行相关性分析。采用受试者操作特征曲线(receiver operating characteristic curve,ROC)分析GDF-15、PPARγ及凝血指标对子痫前期严重程度的预测价值。采用χ^(2)检验和t检验进行统计分析。结果重度组、子痫前期组、对照组GDF-15、PPARγ、FIB水平依次降低,APTT、TT、PT依次升高,差异均有统计学意义(均P<0.05)。GDF-15、PPARγ水平与凝血指标均相关(均P<0.05)。几项指标联合检测的曲线下面积为0.779,灵敏度和特异度分别为75.0%和80.0%。预后良好组GDF-15、PPARγ水平低于预后不良组,差异均有统计学意义(均P<0.05)。结论早发型子痫前期患者血清中GDF-15和PPARγ水平升高,且与凝血功能异常相关,可以作为早期诊断和预测不良预后的生物标志物。Objective To explore the relationship of serum levels of growth differentiation factor 15(GDF-15)and peroxisome proliferator-activated receptorγ(PPARγ)with coagulation indicators in patients with early-onset preeclampsia and their impact on prognosis.Methods Seventy-six patients with early-onset preeclampsia treated at Ankang Maternal and Child Health Hospital from May 2020 to May 2023 were selected as a study group,and 75 healthy pregnant women during the same period a control group.The serum levels of GDF-15 and PPARγ were measured using the enzyme-linked immunosorbent assay.The coagulation function indicators[activated partial thromboplastin time(APTT),thrombin time(TT),prothrombin time(PT),and fibrinogen(FIB)]were detected.The patients were followed up for their prognosis.The correlation of the levels of GDF-15 and PPARγwith coagulation function was analyzed by the Pearson product coefficient.The predictive values of GDF-15,PPARγ,and coagulation indicators for the severity of preeclampsia were analyzed using the receiver operating characteristic curve(ROC).χ^(2) and t tests were used for the statistical analysis.Results The levels of GDF-15,PPARγ,and FIB in the severe group,the preeclampsia group,and the control group sequentially decreased,while the APTT,TT,and PT sequentially increased,with statistical differences(all P<0.05).The levels of GDF-15 and PPARγ were significantly correlated with coagulation indicators(all P<0.05).The area under the curve of the combination of these indicators was 0.779,with a sensitivity of 75.0% and a specificity of 80.0%.The levels of GDF-15 and PPARγin the patients with good prognosis were lower than those in the patients with poor prognosis(both P<0.05).Conclusion Serum levels of GDF-15 and PPARγ are elevated in patients with early-onset preeclampsia and are related to abnormal coagulation function,making them potential biomarkers for early diagnosis and prediction of adverse outcomes.

关 键 词：子痫前期 生长分化因子15 过氧化物酶体增殖物激活受体Γ 凝血指标 相关性 

分 类 号：R714.244[医药卫生—妇产科学]