富血小板纤维蛋白对中度烧伤患者创面愈合及瘢痕的影响  

Effect of Platelet-rich Fibrin on Wound Healing and Scar of Moderate Burn

作　　者：陈维忠 周波 钟清国 钟少州 CHEN Weizhong;ZHOU Bo;ZHONG Qingguo;ZHONG Shaozhou(Department of Emergency Surgery,Ningde Municipal Hospital of Ningde Normal University,Ningde 352100,Fujian,China)

机构地区：[1]宁德师范学院附属宁德市医院急诊外科,福建宁德352100

出　　处：《中国美容医学》2024年第12期39-43,共5页Chinese Journal of Aesthetic Medicine

基　　金：福建医科大学附属协和医院2022年省级重点实验室开放项目(编号:XHZDSYS202203)。

摘　　要：目的:探讨富血小板纤维蛋白(Platelet-rich fibrin,PRF)对中度烧伤创面患者创面愈合及瘢痕外观的影响。方法:选取2022年12月-2023年10月于笔者医院接受治疗的60例中度烧伤患者,采用随机数字表法以1:1比例将患者随机分为对照组与观察组,各30例。对照组采取常规换药治疗,观察组30例采取PRF治疗。比较两组换药次数、肉芽生长时间、创面愈合率、创面愈合时间、创面疼痛情况、创面愈合后瘢痕及患者满意度。结果:与对照组比较,观察组的换药次数明显降低,且肉芽生长时间与创面愈合时间均明显缩短(P<0.05)。治疗后1周、2周及3周,观察组的创面愈合率均高于对照组,而VAS评分均低于对照组(P<0.05)。随访6个月,观察组的VSS评分低于对照组(P<0.05),瘢痕外观满意度高于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:PRF治疗中度烧伤创面能够促进创面愈合,提高创面愈合率及愈合质量,且换药次数更少,能够减轻患者的痛苦,患者满意度高。Objective To investigate the influence of platelet-rich fibrin(PRF)on residual wound healing and scar appearance in patients with moderate burn wounds.Methods Sixty patients with moderate burns treated in the author's hospital from December 2022 to October 2023 were selected.The patients were randomly divided into control group and observation group with a ratio of 1:1 by random number table method,with 30 cases in each group.The control group was treated with routine dressing change,and the observation group was treated with PRF(n=30).The frequency of dressing change,granulation growth time,wound healing rate,wound healing time,wound pain,scar after wound healing and patient satisfaction were compared between the two groups.Results Compared with the control group,the number of dressing changes of observation group was decreased,the granulation growth time and wound healing time was shortened(P<0.05).Compared with the control group,the wound healing rate at 1 week,2 weeks,and 3 weeks after treatment of the observation group had improved(P<0.05).Meanwhile,the VAS score of the observation group showed a decrease compared to the control group(P<0.05).Compared with the control group,the VSS score showed a more decrease in the observation group(P<0.05),and the satisfaction with scar appearance showed a more increase(P<0.05).In terms of adverse reaction rate,there was no difference between the two groups(P>0.05).Conclusion PRF in the treatment of moderate burn wounds can promote wound healing,improve wound healing rate and healing quality,and the number of dressing changes is less,it can reduce the pain of patients,and patient satisfaction is high.

关 键 词：富血小板纤维蛋白 中度烧伤 创面愈合 瘢痕 

分 类 号：R644[医药卫生—外科学]