点阵CO_(2)激光联合30%冰醋酸治疗甲真菌病疗效分析  

Analysis of the Efficacy of Fractional CO_(2) Laser Combined with 30% Glacial Acetic Acid in the Treatment of Onychomycosis

作　　者：李达 涂亚玲 赵菊花 LI Da;TU Yaling;ZHAO Juhua(Department of Dermatology,Nanchong Central Hospital,Nanchong 637000,Sichuan,China)

机构地区：[1]南充市中心医院皮肤科,四川南充637000

出　　处：《中国美容医学》2024年第12期128-131,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨点阵CO_(2)激光联合30%冰醋酸治疗甲真菌病的疗效及对皮肤美观度的影响。方法:选择2022年2月-2023年2月在笔者医院皮肤科就诊的58例甲真菌病患者。对照组病甲外用30%冰醋酸进行治疗,研究组为点阵CO_(2)激光联合30%冰醋酸进行治疗,随访3个月。治疗3个月后评估两组疗效,比较两组治疗满意度,分别于治疗1个月、3个月进行病变/健康甲板长度测量。比较两组不良反应发生情况。结果:研究组治疗总有效率为68.97%,显著高于对照组的41.38%(P<0.05);研究组治疗总满意度为65.52%,显著高于对照组的37.93%(P<0.05);研究组治疗3个月、6个月病变甲板长度均明显短于对照组(P<0.05),健康甲板长度均明显长于对照组(P<0.05);治疗期两组均无甲下出血、缺损等不良反应发生;无肝功肾功能异常;尿、血常规在正常范围。结论:点阵CO_(2)激光结合30%冰醋酸治疗在治疗甲真菌病时,能够有效保护患者的皮肤屏障功能和提升美观度。Objective To investigate the efficacy and aesthetic impact of fractional CO_(2)laser combined with 30%glacial acetic acid in the treatment of onychomycosis.Methods A total of 58 patients with onychomycosis who attended the dermatology clinic of the author’s hospital from February 2022 to February 2023 were selected.The control group received topical treatment with 30%glacial acetic acid,while the study group was treated with a combination of fractional CO_(2)laser and 30%glacial acetic acid,followed by a 3-month follow-up.The efficacy of the treatments was assessed after 3 months,and treatment satisfaction between the two groups was compared.Measurements of the length of diseased and healthy nail plates were conducted at 1 and 3 months post-treatment.The incidence of adverse reactions was also compared between the groups.Results The overall effective rate in the study group was 68.97%,significantly higher than the 41.38%observed in the control group(P<0.05).The overall treatment satisfaction in the study group was 65.52%,markedly higher than the 37.93%in the control group(P<0.05).At both the 3-month and 6-month marks,the length of the diseased nail plate in the study group was significantly shorter than in the control group(P<0.05),while the length of the healthy nail plate was significantly longer(P<0.05).No adverse reactions,such as subungual hemorrhage or nail defects,were reported in either group during the treatment period.Liver and renal function remained normal,and routine urine and blood tests showed no abnormalities.Conclusion The combination of fractional CO_(2)laser with 30%glacial acetic acid is effective in treating onychomycosis,protecting the skin barrier function,and improving aesthetic outcomes.

关 键 词：点阵CO_(2)激光 30%冰醋酸 甲真菌病 疗效 皮肤屏障功能 美观度 

分 类 号：R756.4[医药卫生—皮肤病学与性病学]