塞来昔布联合格列本脲在糖尿病性骨关节病治疗中的价值研究  

Study of the Value of Celecoxib Combine with Glibenclamide in the Treat⁃ment of Diabetic Osteoarthropathy

作　　者：王春瑜 洪淑汾 张喜鹊 WANG Chunyu;HONG Shufen;ZHANG Xique(Nan'an Hospital,Nan'an 362300,Fujian,China)

机构地区：[1]南安市医院,福建南安362300

出　　处：《糖尿病新世界》2024年第19期79-81,85,共4页Diabetes New World

摘　　要：目的探究糖尿病性骨关节病治疗中应用塞来昔布联合格列本脲的价值。方法选取南安市医院于2023年4月—2024年5月收治的118例糖尿病性骨关节病患者为研究对象,按照不同治疗方法分为对照组(阿卡波糖联合塞来昔布治疗)和观察组(塞来昔布联合格列本脲治疗),各59例,对比两组血糖水平、症状改善程度及炎症因子水平。结果治疗后,观察组空腹血糖、餐后2 h血糖水平均低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组白细胞介素-6、肿瘤坏死因子-α及C反应蛋白水平均低于对照组,差异有统计学意义(P均<0.05)。观察组关节肿胀、关节疼痛、关节活动受限及关节晨僵时间均短于对照组,差异有统计学意义(P均<0.05)。结论实施塞来昔布联合格列本脲应用于糖尿病性骨关节病治疗中,可改善其血糖水平,减少不良反应的发生,提升整体疗效。Objective To investigate the value of celecoxib combined with glibenclamide in the treatment of diabetic osteoarthropathy.Methods A total of 118 patients with diabetic osteoarthropathy admitted to Nan'an Hospital from April 2023 to May 2024 were selected as the research objects.According to different treatment methods,they were divided into control group(treated with acarbose combined with celecoxib)and observation group(treated with celecoxib combined with glibenclamide),with 59 cases in each group.The blood glucose level,symptom improvement degree and inflammatory factor levels of the two groups were compared.Results After treatment,the levels of fasting blood glucose and 2-hour postprandial blood glucose in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).After treatment,the levels of interleukin-6,tumor necrosis factor-αand C-reactive protein in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The time of joint swelling,joint pain,joint activity limitation and joint morning stiffness in the observation group were shorter than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion The implementation of celecoxib combined with glibenclamide in the treatment of diabetic osteoarthropathy can improve the blood glucose level,reduce the occurrence of adverse reactions,and improve the overall treatment efficiency.

关 键 词：塞来昔布 格列本脲 糖尿病性骨关节病 血糖水平 不良反应 

分 类 号：R587.1[医药卫生—内分泌]