腰椎间盘突出症患者PELD术后疼痛程度与MRI参数和氧化应激水平的相关性分析  

Correlation Analysis of Postoperative Pain Degree with MRI Parameters and Oxidative Stress Level in Patients with Lumbar Disc Herniation after PELD

作　　者：温进杰[1] 王庆鹏[1] 邵鹏 WEN Jinjie;WANG Qingpeng;SHAO Peng(Department of Spine Surgery,Yantai Laiyang Central Hospital,Yantai 265200,China)

机构地区：[1]山东省烟台市莱阳中心医院脊柱外科,山东烟台265200

出　　处：《中国伤残医学》2024年第17期77-79,83,共4页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探究腰椎间盘突出症患者经皮椎间孔镜髓核摘除术(PELD)术后疼痛程度与MRI参数、氧化应激水平的相关性。方法:选取2021年3月—2023年10月烟台市莱阳中心医院治疗的150例腰椎间盘突出症患者作为研究对象,均行PELD,根据疼痛视觉模拟评分将患者分为恢复良好组(n=102)和恢复不良组(n=48),比较术后4周两组患者的MRI参数(髓核区、纤维环区T2值)、氧化应激水平(血清活性氧、丙二醛、血清总抗氧化能力),并用Pearson分析术后疼痛程度与MRI参数、氧化应激水平的相关性。结果:术后4周,恢复良好组髓核区、纤维环区T2值均高于恢复不良组,血清活性氧、丙二醛、血清总抗氧化能力均低于恢复不良组,差异均有统计学意义(P<0.05)。Pearson相关性分析显示,疼痛程度与髓核区和纤维环区MRI参数、血清活性氧呈负相关,疼痛程度与丙二醛、血清总抗氧化能力正相关。结论:患者疼痛程度与MRI参数与氧化应激水平有关,可通过MRI参数与氧化应激水平预测患者疼痛程度。Objective:To investigate the relationship between postoperative pain degree with MRI parameters and oxidative stress level in patients with lumbar disc herniation after percutaneous endoscopic lumbar discectomy(PELD).Methods:A total of 150 patients with lumbar disc herniation treated in Yantai Laiyang Central Hospital from March 2021 to October 2023 were selected as the study objects.All patients underwent PELD.According to the pain Visual Analogue Scale score,the patients were divided into a good recovery group(n=102)and a poor recovery group(n=48).MRI parameters(T2 values in the nucleus pulposus region and the fibrous ring region)and oxidative stress levels(reactive oxygen species,malondialdehyde and total antioxidant capacity in serum)of the two groups were compared 4 weeks after surgery,and the correlation between postoperative pain degree and MRI parameters and oxidative stress levels was analyzed by Pearson analysis.Results:Four weeks after operation,T2 values in nucleus pulposus and annulus fibrosus in good recovery group were higher than those in poor recovery group,and serum reactive oxygen species,malondialdehyde and total antioxidant capacity in poor recovery group were lower than those in good recovery group,the differences were statistically significant(P<0.05).Pearson correlation analysis showed that pain degree was negatively correlated with MRI parameters in nucleus pulposus and annulus fibrosus and serum reactive oxygen species,while pain degree was positively correlated with malondialdehyde and serum total antioxidant capacity.Conclusion:The pain degree of patients is related to the MRI parameters and the level of oxidative stress.The pain degree of patients can be predicted by MRI parameters and the level of oxidative stress.

关 键 词：腰椎间盘突出症 经皮椎间孔镜髓核摘除术术后 疼痛程度 MRI参数 氧化应激水平 

分 类 号：R687[医药卫生—骨科学]