基于数据挖掘技术探讨中医药治疗咳嗽变异性哮喘经验  

The Experience of Traditional Chinese Medicine in Treating Cough VariantAsthma was Discussed Based on Data Mining Technology

作　　者：宋春玲 余松 周运海[1] Song Chunling;Yu Song;Zhou Yunhai(Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou 215000,China)

机构地区：[1]南京中医药大学附属苏州市中医医院,江苏苏州215000

出　　处：《亚太传统医药》2024年第8期196-201,共6页Asia-Pacific Traditional Medicine

基　　金：苏州市“科教兴卫”青年科技项目(KJXW2021048)。

摘　　要：目的:利用数据挖掘技术,探讨周运海主任中医师治疗咳嗽变异性哮喘的用药规律。方法:检索周运海主任中医师中医诊断为“咳嗽病”、西医诊断为“咳嗽变异性哮喘”的门诊病例,记录时间为2020年1月1日-2022年12月31日。运用Python 2.7、R语言V4.2.2、SPSS Modeler 18.0、SPSS Statistic 28.0进行频数分析、关联规则分析、复杂网络分析、聚类分析等。结果:经检索的218张处方中,患者舌脉以舌苔薄白腻、舌质轻度齿痕、脉软为主要特征;临证用药以温、寒、平性为主,药味以苦、辛、甘味为主,归经以肺、胃、肝、脾经为主;药物功效统计以止咳平喘药最多;用药频次≥50次者,共计23味,前10位依次为桑白皮、甘草、蜜紫菀、蜜麻黄、醋乌梅、黛蛤散、木蝴蝶、辛夷、西青果、僵蚕;关联分析得出:桑白皮、蜜麻黄、蜜紫菀、醋乌梅、黛蛤散、木蝴蝶之间关联密切;复杂网络分析表明,桑白皮是最核心的药物;聚类分析得出7个聚类处方,包括辛夷、苍耳子、黑大豆衣、蜜麻黄、醋乌梅、桑白皮等。结论:周运海主任中医师治疗咳嗽变异性哮喘注重寒热同调、升降相依、肝升肺降、中气运转,特色鲜明,疗效明确。Objective:Using data mining technology to explore the medication pattern of director physician of traditional Chinese medicine Zhou Yunhai in treating cough variant asthma.Methods:Outpatient cases diagnosed as cough disease in Chinese medicine and cough variant asthma in Western medicine from January 1,2020 to December 31,2022 in the outpatient system of director physician of traditional Chinese medicine Yunhai Zhou were retrieved and analyzed using Python 2.7,R language V4.2.2,SPSS Modeler 18.0,and SPSS Statistic 28.0 for frequency analysis,association rule analysis,complex network analysis,and cluster analysis.Results:The patients'tongues and pulses in the 218 prescriptions retrieved mainly showed thin white and greasy tongue coating,mildly toothed tongue,and soft pulse.The clinical evidence of drug use was mostly warm,cold,and flat,the taste of drugs was mainly bitter,pungent,and sweet,and the normalization was mainly lung,stomach,liver,and spleen meridians.The drug efficacy statistics were most frequently used to stop cough and calm asthma.The frequency of use≥50 times a total of 23 drugs,the top 10 drugs are mulberry bark,licorice,honey aster,honey ephedra,vinegar umeboshi,dai clam san,wood butterfly,xin yi,xi qing guo,stiff silkworm.The correlation analysis yielded a close correlation between mulberry bark,honey ephedra,honey aster,vinegar umeboshi,dai clam san,and wood butterfly.The complex network analysis showed that the core drug was mulberry bark.The cluster analysis yielded seven prescriptions:sinapis,cang er zi,black soybean coat,honey ephedra,vinegar ume,and mulberry bark.Conclusion:Director physician of traditional Chinese medicine Zhou Yunhai's treatment of cough variant asthma focuses on simultaneous regulation of cold and heat,elevation and declination,elevation of the liver and lowering of the lung,and operation of the middle qi,with distinctive features and clear curative effects.

关 键 词：咳嗽变异性哮喘 数据挖掘 频数分析 关联分析 聚类分析 

分 类 号：R256.1[医药卫生—中医内科学]