水飞蓟提取物对大鼠的28 d经口毒性  

The 28-day oral toxicity of the extract of Silybum marianum in rats

作　　者：姬海南 赵潺 林子君 佟娜 陈博文 周时蒙 刘鸣畅[1] 沈国林[1] 张梦玲 JI Hainan;ZHAO Chan;LIN Zijun;TONG Na;CHEN Bowen;ZHOU Shimeng;LIU Mingchang;SHEN Guolin;ZHANG Mengling(Institute of Chemicals Safety,Chinese Academy of Inspection and Quarantine,Beijing 100176,China;Center for Food Evaluation,State Administration for Market Regulation,Beijing 100022,China;Comprehensive Testing Center,Chinese Academy of Inspection and Quarantine,Beijing 100176,China)

机构地区：[1]中国检验检疫科学研究院化学品安全研究所,北京100176 [2]国家市场监督管理总局食品审评中心,北京100022 [3]中国检验检疫科学研究院综合检测中心,北京100176

出　　处：《食品与机械》2024年第10期136-147,共12页Food and Machinery

基　　金：国家市场监督管理总局化学品质量安全监测能力提升专项(编号:2013810-24-004)。

摘　　要：[目的]评价水飞蓟提取物对大鼠的28 d经口毒性。[方法]采用SD大鼠作为模式动物,研究水飞蓟提取物对大鼠体重及器官系数、生化指标、血常规及血凝指标、肝脏病理的影响并探讨其安全性。[结果]水飞蓟提取物对大鼠体重及器官系数、生化指标、血常规及血凝指标、肝脏病理学均无不利影响。水飞蓟提取物干预可能通过调节大鼠血浆氨基酸代谢信号通路以及肝脏核黄素代谢、淀粉和蔗糖代谢、鞘脂代谢信号通路,促进大鼠机体健康。[结论]在试验研究的剂量和条件下,水飞蓟提取物安全性好。[Objective]This study aimed to assess the 28-day oral toxicity of Sihbum manalttlm extract in rats.[Methods]SD rats were administered S.manalttlm extract,and effects on body weight,organ coefficients,biochemical indicators,blood routine and hemagglutination indicators,and liver pathology were evaluated to determine safety.[Results]S.manalttlm extract showed no adverse effects on body weight,organ coefficients,biochemical indicators,blood routine and coagulation indicators,or liver pathology.Additionally,S.manalttlm extract appeared to positively influence pathways related to plasma amino acid metabolism,liver riboflavin metabolism,carbohydrate metabolism,and sphingolipid metabolism,contributing to overall health benefits in rats.[Conclusion]S.manalttlm extract was deemed safe Under the dosage and conditions of this study.

关 键 词：水飞蓟 毒性研究 肝脏 血浆 代谢组学 

分 类 号：TS201.6[轻工技术与工程—食品科学]