青礞石治疗癫痫的作用机制及临床应用研究进展  

Progress on Mechanism of Action and Clinical Application of Chloriti Lapis in the Treatment of Epilepsy

作　　者：吴广 铁梦意 杨俊红[1] 朱健 潘知玉 刘金民[4] 荆志伟[3] WU Guang;TIE Mengyi;YANG Junhong;ZHU Jian;PAN Zhiyu;LIU Jinmin;JING Zhiwei(Dept.of Encephalopathy,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;the First Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450046,China;Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Dept.of Encephalopathy,Dongfang Hospital of Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]河南中医药大学第一附属医院脑病科,郑州450000 [2]河南中医药大学第一临床医学院,郑州450046 [3]中国中医科学院中医临床基础医学研究所,北京100700 [4]北京中医药大学东方医院脑病科,北京100078

出　　处：《中国医院用药评价与分析》2024年第11期1397-1401,1408,共6页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：国家自然科学基金资助项目(No.82074584);中国中医科学院科技创新工程项目(No.CI2021A04702)。

摘　　要：青礞石作为矿物类中药,味甘、咸,性平,归肺、心、肝经,具有坠痰下气、平肝镇惊之功,用于顽痰胶结、咳逆喘急、癫痫发狂、烦躁胸闷、惊风抽搐。研究结果表明,青礞石能够减少海马神经元凋亡,抑制炎症因子过度表达,抑制兴奋性神经递质从而减少大脑异常放电,干预肠道微生态的重建、降低变形菌门的丰富度从而通过“脑肠轴”抑制癫痫样放电。临床研究结果证实,青礞石抗癫痫疗效显著。笔者通过查阅相关文献,探讨了青礞石治疗癫痫的作用机制及临床应用,以期为临床中药新药的研发提供参考。Chloriti Lapis,as a mineral medicine,is sweet and salty in taste,neutral in nature,and enters the lung,heart,and liver meridians.It has the functions of resolving phlegm,descending Qi,soothing the liver,and calming the mind.It is used for conditions such as stubborn phlegm accumulation,cough with dyspnea,epilepsy with mania,irritability,chest tightness,and convulsions due to fright.Studies have shown that Chloriti Lapis can reduce the hippocampal neuron apoptosis,inhibit the excessive expression of inflammatory factors,inhibit the excitatory neurotransmitters to reduce abnormal brain discharges,and interfere with the reconstruction of intestinal microecology by reducing the abundance of Proteobacteria,thereby inhibiting epileptic discharges through the“cerebro-intestinal axis”.Clinical studies have confirmed the significant anti-epileptic efficacy of Chloriti Lapis.By reviewing relevant literature,this article explores the mechanism of action and clinical application of Chloriti Lapis in the treatment of epilepsy,aiming to provide reference for the development of new clinical traditional Chinese medicines.

关 键 词：青礞石 癫痫 作用机制 临床应用 研究进展 

分 类 号：R932[医药卫生—生药学]