参杞强精颗粒质量标准提升研究  

Improving on Quality Standard of Shenqi Qiangjing Granules

作　　者：刘金花 傅静 李晓霞 何泳昌 唐爱存[1] Liu Jinhua;Fu Jing;Li Xiaoxia;He Yongchang;Tang Aicun(The First Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530023,China)

机构地区：[1]广西中医药大学第一附属医院,广西南宁530023

出　　处：《亚太传统医药》2024年第9期38-41,共4页Asia-Pacific Traditional Medicine

基　　金：广西重点研发计划项目(桂科AB22035073);广西中医药适宜技术开发与推广项目(GZSY22-18);广西中医药管理局科研课题(GXZYA20230085,GXZYA20220180)。

摘　　要：目的:提高参杞强精颗粒内控标准,更好地控制颗粒质量。方法:新增黄芪和续断的薄层色谱鉴别,采用高效液相色谱法对淫羊藿苷、毛蕊异黄酮苷的定量测定。结果:黄芪和续断的色谱斑点清晰,阴性无干扰;淫羊藿苷、毛蕊异黄酮苷分别在0.31~3.1μg/μL、0.0344~0.344μg/μL范围内呈良好线性关系,平均加样回收率分别为103.43%(RSD=1.77%)、92.56%(RSD=1.43%)。结论:黄芪和续断的薄层色谱鉴别方法专属性较强;淫羊藿苷和毛蕊异黄酮苷的含量测定方法准确性较高,为参杞强精颗粒的质量提升提供了依据。Objective:To improve the Internal control standard for Shenqi Qiangjing Granules and better control the quality of granules.Methods:The qualitative identifications of Radix Astragali and Radix Dipsaci by TLC were increased,HPLC was used for the content determination of Icariin and Calycosin-7-glucoside.Results:TLC methods of Radix Astragali and Radix Dipsaci showed that chromatographic spots were clear,negative without interference.Icariin and Calycosin-7-glucoside showed good linear relationship in the range of 0.31-3.1μg/μL and 0.0344-0.344μg/μL,respectively.The average recoveries of Icariin and Calycosin-7-glucoside were 103.43%(RSD=1.77%)and 92.56%(RSD=1.43%)respectively.Conclusion:The TLC identification methods of Radix Astragali and Radix Dipsaci have strong specificity;the content determination of Icariin and Calycosin-7-glucoside have high accuracy,which can be used for the quality control of Shenqi Qiangjing Granules.

关 键 词：参杞强精颗粒 黄芪 续断 淫羊藿苷 毛蕊异黄酮苷 标准提高 

分 类 号：R284[医药卫生—中药学]