血清肌红蛋白和肌钙蛋白I与冠状动脉粥样硬化性心脏病患者冠状动脉病变严重程度的关联性分析  

Correlation between serum myoglobin,troponinⅠand severity of coronary artery lesions in patients with coronary atherosclerotic heart disease

作　　者：朱秋平 刘翩 路文哲 Zhu Qiuping;Liu Pian;Lu Wenzhe(Department of Cardiovascular Medicine,the Ninth People's Hospital of Zhengzhou,Zhengzhou,Henan 450000,China)

机构地区：[1]郑州市第九人民医院心血管内科,河南郑州450000

出　　处：《感染、炎症、修复》2024年第3期196-199,共4页Infection Inflammation Repair

摘　　要：目的:探讨血清肌红蛋白(Mb)和肌钙蛋白I(cTnI)与冠状动脉粥样硬化性心脏病(CHD)患者冠状动脉(冠脉)病变严重程度的关联性。方法:采用回顾性研究方法,选取2019年5月至2023年7月于郑州市第九人民医院住院且经冠脉造影证实为CHD的82例患者为CHD组,另选取同期于同一家医院体检的78例健康人为对照组。比较CHD组、对照组血清Mb和cTnI水平;比较CHD组不同冠脉病变严重程度患者血清Mb和cTnI水平;将Mb和cTnI分别按照正常界值上限进行分组,比较Mb<75μg/L与Mb≥75μg/L、cTnI<1.0 mg/L与cTnI≥1.0 mg/L者冠脉狭窄Gensini评分的差异。通过二元回归方法分析Mb和cTnI与冠脉病变严重程度的关系,列出回归方程。结果:CHD组血清Mb和cTnI水平较对照组更高(P<0.05)。不同冠脉病变严重程度的CHD患者血清Mb和cTnI水平存在统计学差异(P<0.05),中、重度组高于轻度组,重度组高于中度组(P<0.05)。Mb<75μg/L 10例与Mb≥75μg/L 72例之间、cTnI<1.0 mg/L 7例与cTnI≥1.0 mg/L 75例之间Gensini评分均存在显著的统计学意义(P<0.05)。血清Mb和cTnI水平与CHD组不同冠脉病变严重程度Gensini评分的二元线性回归方程为Y=15.372+2.815X1+1.030X2(Y为Gensini评分,X_(1)为血清Mb,X_(2)为血清cTnI),血清Mb和cTnI水平与CHD组冠脉病变严重程度呈正相关(r=0.557、0.510,P<0.05)。结论:血清Mb和cTnI水平与CHD患者冠脉病变严重程度存在显著正相关关系。本研究结果为CHD临床诊疗提供了新的参考依据,也为进一步探讨CHD发病机制和预防策略提供了新思路。Objective:To investigate the correlation between serum myoglobin(Mb),troponinⅠ(cTnI)and the severity of coronary lesions in patients with coronary atherosclerotic heart disease(CHD).Methods:A total of 82 patients admitted to the Ninth People's Hospital of Zhengzhou from May 2019 to July 2023 and confirmed as CHD by coronary angiography were selected as the CHD group,which was retrospectively analyzed.Another 78 healthy cases who underwent physical examination in the same hospital during the same period were selected as control group.Serum Mb and cTnI levels were compared between the CHD group and the control group,the serum levels of Mb and cTnI in CHD patients with different degrees of coronary artery disease severity were compared.Mb and cTnI were grouped according to the upper limit of normal threshold,and the differences of Gensini scores in patients with coronary artery stenosis were compared between Mb<75μg/L and Mb≥75μg/L,cTnI<1.0 mg/L and cTnI≥1.0 mg/L.The relationship between Mb,cTnI and the severity of coronary artery disease was analyzed by binary regression method,and the regression equation was listed.Results:Serum Mb and cTnI levels in the CHD group were higher than those of control group(P<0.05).There were statistical differences in serum Mb and cTnI levels in CHD patients with different coronary lesion severities(P<0.05);serum Mb and cTnI levels were higher in the moderate and severe groups than those in the mild group,and serum Mb and cTnI levels were higher in the severe group than those in the moderate group,the severe group was higher than moderate group(P<0.05).There were statistically significant Gensini scores 10 cases with Mb<75μg/L and 72 cases with Mb≥75μg/L;7 cases with cTnI<1.0 mg/L and 75 cases cases with cTnI≥1.0 mg/L,respectively,(P<0.05).The binary linear regression equation of serum Mb and cTnI levels and Gensini score of different severity of coronary lesions in the CHD group was Y=15.372+2.815X1+1.030X2(Y is Gensini score,X1 is serum Mb,and X2 is serum cTnI).Serum

关 键 词：冠状动脉粥样硬化性心脏病 肌红蛋白 肌钙蛋白Ⅰ GENSINI评分 冠状动脉狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]