广西南宁地区45578例急性呼吸道感染患儿9种病原体IgM抗体检测结果分析  

Analysis of IgM antibody detection results of 9 pathogens in 45578 children with acute respiratory tract infection in Nanning area of Guangxi

作　　者：陈德敏[1] 李东明[1] 黄强 兰访 CHEN Demin;LI Dongming;HUANG Qiang;LAN Fang(Department of Clinical Laboratory Examination,Maternal and Children Health Hospital of Guangxi Zhuang Autonomous Region,Nanning,Guangxi 530003,China)

机构地区：[1]广西壮族自治区妇幼保健院检验科,广西南宁530003

出　　处：《检验医学与临床》2024年第23期3425-3430,共6页Laboratory Medicine and Clinic

基　　金：广西壮族自治区卫生健康委员会自筹科研课题项目(Z-A20240317,Z-A20222076)。

摘　　要：目的分析广西南宁地区急性呼吸道感染患儿病原体检出情况以及流行特点。方法回顾性分析2019年1月至2022年12月在广西壮族自治区妇幼保健院因急性呼吸道感染就诊的45578例患儿9种病原体[嗜肺军团菌(LP)、肺炎支原体(MP)、肺炎衣原体(CP)、Q热立克次体(COX)、腺病毒(ADV)、呼吸道合胞病毒(RSV)、甲型流感病毒(INFA)、乙型流感病毒(INFB)和副流感病毒(PIVs)]免疫球蛋白M(IgM)抗体检出情况,分析南宁地区儿童急性呼吸道感染的流行特点。结果45578例患儿中,有20059例检出病原体,总检出率为44.01%;≥2种病原体感染2557例,占12.75%(2557/20059),其中检出率最高的3种病原体分别为MP[39.68%(18085/45578)]、INFB[3.12%(1421/45578)]、PIVs[2.74%(1248/45578)]。冬季病原体检出率最高,为52.32%[(6005/11478)],明显高于春季[51.58%(5059/9809)]、夏季[51.10%(5631/11020)]和秋季[46.79%(6209/13271)],差异均有统计学意义(P<0.05)。在不同年龄段患儿中,>3~14岁患儿的病原体检出率最高,为67.92%;女性患儿病原体检出率为59.51%,高于男性患儿的44.36%(P<0.001);在不同疾病患儿中,支气管炎患儿病原体总检出率最高,为56.18%。结论2019-2022年南宁地区急性呼吸道感染患儿病原体主要为MP、INFB和PIVs,且以冬季感染为主,多感染>3~14儿童,尤其是女童。Objective To analyze the detection of pathogens of acute respiratory infections in children in Nanning area as well as the epidemiological characteristics.Methods Retrospective analysis of immune globulin M(IgM)antibody detection results of 9 pathogens[Legionella pneumophila(LP),Mycoplasma pneumoniae(MP),Chlamydia pneumoniae(CP),Coxiella burnetii q fever(COX),adenovirus(ADV),respiratory syncytial virus(RSV),influenza A virus(INFA),influenza B virus(INFB)and Parainfluenza viruses(PIVs)]in 45578 children with acute respiratory tract infections,who were treated in Maternal and Children Health Hospital of Guangxi Zhuang Autonomous Region from January 2019 to December 2022,was conducted.The epidemiological characteristics of children with acute respiratory tract infections in Nanning were analyze statistically.Results Among 45578 children with acute respiratory tract infections,pathogens were detected in 20059 cases,with a total detection rate of 44.01%,and 2557 cases were infected with≥2 pathogens,accounting for 12.75%(2557/20059),with top three higher detection rate of infectious pathogens of MP[39.68%(18085/45578)],INFB[3.12%(1421/45578)]and PIVs[2.74%(1248/45578)].The pathogen detection rate was the highest in winter[52.32%(6005/11,478)],which was significantly higher than that in spring[51.58%(5059/9809)],summer[51.10%(5631/11020)]and fall[46.79%(6209/13271)],with statistically significant differences(P<0.05).In children with different ages,the highest pathogen detection rate was 67.92%in children with>3-14 years old;the pathogen detection rate in female children was 59.51%,which was higher than 44.36%in male children;in children with different diseases,the highest total pathogen detection rate was 56.18%in children with bronchiolitis.Conclusion The pathogens of children with acute respiratory infections in Nanning area in 2019-2022 are mainly MP,INFB and PIVs,mixed infections are more common,and infections are predominantly in winter,mostly infecting children with>3-14 years old,especially girls.

关 键 词：急性呼吸道感染 儿童 流行病学 肺炎支原体 甲型流感病毒 副流感病毒 

分 类 号：R725.6[医药卫生—儿科] R446.4[医药卫生—临床医学]