少腹逐瘀汤不同给药方式治疗寒湿凝滞型盆腔炎性疾病后遗症疗效观察  

Efficacy of different administration modes of lesser abdomen stasis-expelling decoction on the sequelae of pelvic inflammatory disease of type of cold-damp stagnation

作　　者：薛玲 孙蓉蓉 郑伟 宁婕 XUE Ling;SUN Rongrong;ZHENG Wei;NING Jie(Qingdao Hospital of Integrated Traditional Chinese and Western Medicine,Qingdao 266002,Shandong,China)

机构地区：[1]山东青岛中西医结合医院,山东青岛266002

出　　处：《现代中西医结合杂志》2024年第19期2655-2659,2717,共6页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：青岛市医药科研指导计划项目(2019-WJZD099);青岛市中医药科研计划项目(2019-zyj008)。

摘　　要：目的比较少腹逐瘀汤不同给药方式治疗寒湿凝滞型盆腔炎性疾病后遗症(SPID)患者的临床疗效及对血清补体和炎症因子的影响。方法将2020年7月—2022年3月山东青岛中西医结合医院诊治的105例寒湿凝滞型SPID患者随机分成对照组、试验1组和试验2组,每组35例,分别采用少腹逐瘀汤口服、灌肠、隔药灸的方式给药,均连续治疗3个月经周期。观察治疗前后3组患者临床表现(局部体征、中医证候)变化,检测血清补体(C3、C4)与炎症相关因子[降钙素原(PCT)、白细胞介素-6(IL-6)]水平,记录治疗过程中药物不良反应发生情况及停药6个月后疾病复发情况。结果对照组和试验1组各有1例患者中途退出,不计入统计。治疗后3组患者局部体征总分及单项体征评分、中医证候总分及单项症状评分均明显低于治疗前(P均<0.05),试验2组局部体征总分和中医证候总分均明显低于对照组和试验1组(P均<0.05)。治疗后3组患者血清补体C3水平均明显高于治疗前(P均<0.05),血清PCT、IL-6水平均明显低于治疗前(P均<0.05),且试验2组血清补体C3水平明显高于对照组和试验1组(P均<0.05),血清IL-6水平明显低于对照组和试验1组(P均<0.05)。3组治疗期间均无不良反应发生。随访时试验2组复发率明显低于对照组和试验1组[14.28%(5/35)比41.17%(14/34)、35.29%(12/34),P均<0.05]。结论少腹逐瘀汤隔药灸治疗寒湿凝滞型SPID能更有效地调节机体免疫功能,减轻炎性反应,临床疗效显著且复发率低,效果优于口服或直肠给药。Objective It is to compare the clinical efficacies of different administration modes of lesser abdomen stasis-expelling decoction on the sequelae of pelvic inflammatory disease(SPID)of type of cold-damp stagnation and its influences on serum complements and inflammation factors.Methods One hundred and five patients with SPID of type of cold-damp stagnation treated in Qingdao Hospital of Integrated Traditional Chinese and Western Medicine from July 2020 to March 2022 were randomly divided into control group,test groupⅠand test groupⅡ,with 35 patients in each group,and were respectively treated with lesser abdomen stasis-expelling decoction by oral administration,enema and isolation medicine moxibustion,all the three groups were continuously treated for 3 menstrual cycles.The clinical manifestations(local signs and syndrome of traditional Chinese medicine)were observed,and the serum levels of complement(C3,C4)and inflammation-related factors[procalcitonin(PCT),interleukin-6(IL-6)]were detected in patients of the three groups before and after treatment,and the occurrence of adverse drug reactions during treatment and the recurrence of the disease after 6 months of drug withdrawal were recorded.Results One patient in each of the control group and test groupⅠdropped out and was not counted.After treatment,the total score of local signs and scores of single sign,the total score of traditional Chinese medicine syndrome and scores of single symptom of the three groups were significantly lower than those before treatment(all P<0.05),and the total score of local signs and total score of traditional Chinese medicine syndrome of the test groupⅡwere significantly lower than those of the control group and test groupⅠ(all P<0.05).After treatment,the serum levels of complement C3 of the three groups were significantly higher than those before treatment(all P<0.05),while the serum levels of PCT and IL-6 were significantly lower than those before treatment(all P<0.05),and the serum level of complement C3 of the test grou

关 键 词：少腹逐瘀汤 盆腔炎性疾病后遗症 隔药灸 血清补体 炎症因子 

分 类 号：R711.33[医药卫生—妇产科学]