化浊解毒法治疗慢性萎缩性胃炎疗效Meta分析  

Meta Analysis of the Efficacy of Removing Turbidity and Detoxification in theTreatment of Chronic Atrophic Gastritis

作　　者：王杰 才艳茹 杜姚[1,2,3] 杜朋丽 贾雪梅 郭榆西 李博林 杨倩[1,2,3] Wang Jie;Cai Yanru;Du Yao;Du Pengli;Jia Xuemei;Guo Yuxi;Li Bolin;Yang Qian(Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang 050011,China;Key Laboratory of Turbidity and Poison Syndrome in Hebei Province,Shijiazhuang 050011,China;Key Laboratory of Integrated Traditional Chinese and Western Medicine Gastrointestinal Disease Research in Hebei Province,Shijiazhuang 050011,China;Hebei University of Chinese Medicine,Shijiazhuang 050091,China)

机构地区：[1]河北省中医院,河北石家庄050011 [2]河北省浊毒证重点实验室,河北石家庄050011 [3]河北省中西医结合胃肠病研究重点实验室,河北石家庄050011 [4]河北中医药大学,河北石家庄050091

出　　处：《亚太传统医药》2024年第12期153-161,共9页Asia-Pacific Traditional Medicine

基　　金：国家中医临床研究基地建设项目(国中医药办科技函[2018]131号);国家重点研发计划项目(2018YFC1704100,2018YFC1704102);河北省省级科技计划资助项目(21377724D,21377740D);河北省中医药管理局科研计划项目(2021034,2022026,2022032,2023022);河北省政府资助临床医学优秀人才培养项目(ZF2023162);河北省博士后科研择优资助项目(B2023003037)。

摘　　要：目的:评价化浊解毒法治疗慢性萎缩性胃炎(CAG)的有效性,为临床治疗提供参考依据。方法:以化浊解毒法治疗CAG相关研究为关键词检索中国知网(CNKI)、万方数据库(WanFang)、维普数据库(VIP)、中国生物医学文献数据库(CBM)等,收集发表的有关化浊解毒法方药对比常规西医或中成药治疗CAG的临床研究。应用RevMan 5.3软件对符合纳入标准的临床研究进行Meta分析。结果:化浊解毒法治疗CAG患者,可提高临床总有效率:RR=1.31,95%CI[1.25,1.37],P<0.00001;胃镜疗效:RR=1.39,95%CI[1.28,1.50],P<0.00001;病理疗效:RR=1.29,95%CI[1.19,1.39],P<0.00001;改善胃痛评分:SMD=-1.56,95%CI[-2.13,-0.98],P<0.00001;胃胀评分:SMD=-1.58,95%CI[-2.22,-0.93],P<0.00001,在不良事件发生率方面,差异不明显。结论:化浊解毒法治疗CAG在提高临床总有效率、改善胃镜病理表现、减轻中医症状(胃痛、胃胀)等方面的作用效果优于中成药或西药对照组。Objective:To evaluate the effectiveness of removing turbidity and detoxification in the treatment of chronic atrophic gastritis(CAG),so as to provide a reliable basis for clinical treatment.Methods:Search China knowledge Network(CNKI),WanFang Database,VIP Database(VIP),China Biomedical Literature Database(CBM)and other key words related to the treatment of CAG with the method of removing turbidity and detoxification,and collect and compare the clinical studies of routine western medicine or proprietary Chinese medicine in the treatment of CAG.Meta analysis was performed on clinical studies that met the inclusion criteria using RevMan 5.3 software.Results:The treatment of CAG patients with removing trubidity and detoxification Jiedu method can improve the total clinical effective rate:RR=1.31,95%CI[1.25,1.37],P<0.00001;Gastroscopy efficacy:RR=1.39,95%CI[1.28,1.50],P<0.00001;The pathological curative effect:RR=1.29,95%CI[1.19,1.39],P<0.00001;Improvement of stomach pain score:SMD=-1.56,95%CI[-2.13,-0.98],P<0.00001;Stomach distension score:SMD=-1.58,95%CI[-2.22,-0.93],P<0.00001,in the incidence of adverse events,the difference was not significant.Conclusion:The method of removing turbidity and detoxification in the treatment of CAG is superior to the control group of Chinese patent medicine or western medicine in improving the total clinical effective rate,improving the pathological manifestations of gastroscopy and alleviating the symptoms of traditional Chinese medicine(stomach pain,stomach distension).

关 键 词：化浊解毒法 慢性萎缩性胃炎 疗效 META分析 

分 类 号：R256.3[医药卫生—中医内科学]