阿那日五味散方源考证及治疗高脂血症作用机制预测  

Research on the Origin of Anari Wuwei Powder and Prediction of the Mechanism of Action in Treating Hyperlipidemia

作　　者：安其力木格 胡伊力格其[1,2] 白小梅 白梅荣 敖日格乐[1,3] Anqi Limuge;Huyi Ligeqi;Bai Xiaomei;Bai Meirong;Aori Gele(College of Mongolia Medicine and Pharmacology,Inner Mongolia Minzu University,Tongliao 028000,China;Key Laboratory of Mongolian Medicine Research and Development Engineering,Ministry of Education,Tongliao 028000,China;NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine(Mongolian Medicine),Tongliao 028000,China)

机构地区：[1]内蒙古民族大学蒙医药学院,内蒙古通辽028000 [2]蒙医药研发工程教育部重点实验室,内蒙古通辽028000 [3]国家药品监督管理局中药(蒙药)质量控制重点实验室,内蒙古通辽028000

出　　处：《亚太传统医药》2024年第11期86-92,共7页Asia-Pacific Traditional Medicine

基　　金：内蒙古自治区自然科学基金项目(2018LH08063);内蒙古自治区高等学校蒙药安全评价“创新团队”项目(NMGIRT2216);内蒙古民族大学中药学(蒙药学)重点学科建设项目(ZYX005);内蒙古民族大学博士科研启动基金(BS598)。

摘　　要：蒙药阿那日五味散收载于《中华人民共和国卫生部药品标准》蒙药分册,由全石榴、荜茇、豆蔻、肉桂、干姜配伍组成,有消食、温胃的作用,主治消化不良、肾寒腰痛、胃脘寒湿等。蒙医在使用过程中,根据复方单味药配伍及入药剂量不同而复方疗效也有所不同。通过进行方源考证、方解分析以及利用网络药理学预测阿那日五味散治疗高脂血症的作用靶点,探索其作用机制,为阿那日五味散的临床应用和进一步开发利用提供参考依据。Mongolian Medicine Anari Wuwei Powder is included in The Pharmaceutical Standards of Ministry of Health of the People's Republic of China(Mongolian Medicine).It is composed of whole pomegranate,cassia bark,cardamom,Long Pepper and dried ginger,which is warm to the stomach,soothing to the stomach,treating cold dampness,dyspepsia,cold kidney and lumbago.In the course of using Mongolian medicine,the effect of the compound medicine is different according to the compatibility and dosage of the compound medicine.In this paper,through the research of the source of the prescription,the analysis of the solution,and the prediction of the target of the action of Anari Wuwei Powder in the treatment of hyperlipidemia by using network pharmacology,the mechanism of action was explored.and provide reference for the clinical application and further development of Anari Wuwei Powder.

关 键 词：阿那日五味散 方源考证 方解 网络药理学 高脂血症 

分 类 号：R29[医药卫生—民族医学] R259[医药卫生—中医学]