中西医调控PI3K/AKT/FOXO3a信号通路治疗卵巢早衰研究进展  

Research Progress of PI3K/AKT/FOXO3a Signal Pathway Regulated by Traditional Chinese and Western Medicine in the Treatment of Premature Ovarian Failure

作　　者：代雅婷 李晶[1] 张怡 王蓉[1] 水蓉枝 李新梅 王新斌[1] Dai Yating;Li Jing;Zhang Yi;Wang Rong;Shui Rongzhi;Li Xinmei;Wang Xinbin(Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000

出　　处：《亚太传统医药》2024年第11期247-250,共4页Asia-Pacific Traditional Medicine

基　　金：甘肃省自然科学基金(23JRRA1206);甘肃省高校教师创新基金项目(2023B-109)。

摘　　要：卵巢早衰是一种原发性卵巢缺陷的异质性疾病。因其病因不明,该病的治疗也成为一大难点。随着医学的发展,西医治疗卵巢早衰可采用间充质干细胞(MSCs)移植方法,为卵巢早衰治疗提供了新前景。同时研究发现中药单体或复方可通过多途径、多角度对卵巢早衰起到一定的治疗效果。基于目前对卵巢早衰的研究现状,阐述卵巢早衰与PI3K/AKT/FOXO3a信号通路的关系,并基于该关系总结归纳了中西医对卵巢早衰的干预机制及功效的研究进展,为今后治疗卵巢早衰奠定了理论基础。Premature ovarian failure is a heterogeneous disease with primary ovarian defects.Because the cause of the disease is unknown,the treatment of the disease has become a major difficulty.With the development of medicine,mesenchymal stem cell(MSCs)transplantation can be used in Western medicine to treat premature ovarian failure,which provides a new prospect for premature ovarian failure treatment.At the same time,it was found that TCM monomer or compound can play a certain therapeutic effect on premature ovarian failure through multiple ways and angles.Based on the current research status of premature ovarian failure,this paper expounds the relationship between premature ovarian failure and PI3K/AKT/FOXO3a signaling pathway,and summarizes the research progress on the intervention mechanism and efficacy of Chinese and Western medicine on premature ovarian failure based on this relationship,which lays a certain theoretical foundation for the future treatment of premature ovarian failure.

关 键 词：卵巢早衰 PI3K/AKT/FOXO3a 中药单体或复方 间充质干细胞 

分 类 号：R271.9[医药卫生—中西医结合]