羊布鲁氏菌病生物安全相关风险因素及群流行率Meta分析  

Meta-analysis on Biosafety Risk Factors and Herd Prevalence of Ovine Brucellosis

作　　者：王新 张涛 刘健[2] 张靖飞 刘贺[3] 冯鹏 高娟 吴萌萌 石龙飞 白东宁 李俊生 吴洪涛 薛佳佳 李扬帆 徐琨 Wang Xin;Zhang Tao;Liu Jian;Zhang Jingfei;Liu He;Feng Peng;Gao Juan;Wu Mengmeng;Shi Longfei;Bai Dongning;Li Junsheng;Wu Hongtao;Xue Jiaja;Li Yangfan;Xu Kun(Xi'an Animal Disease Prevention and Control Center,Xi'an 71006l,Shannxi,China;Shanghai Animal Disease Prevention and Control Center,Shanghai 201103,China;Fushun Animal Disease Prevention and Control Center,Fushun 113013,Liaoning,China;Baqiao District Animal Disease Prevention and Control Center,Xi'an 710024,Shannxi,China;Liaoning Provincial Agricultural Development Service Center,Shenyang 111200,Liaoning,China;Xi'an Disease Prevention and Control Center,Xi'an 710054,Shannxi,China)

机构地区：[1]西安市动物疫病预防控制中心,陕西西安710061 [2]上海市动物疫病预防控制中心,上海2201103 [3]抚顺市动物疫病预防控制中心,辽宁抚顺113013 [4]西安市灞桥区动物疫病预防控制中心,陕西西安710024 [5]辽宁省农业发展服务中心,辽宁沈阳111200 [6]西安市疾病预防控制中心,陕西西安710054

出　　处：《中国动物检疫》2024年第11期43-49,共7页China Animal Health Inspection

基　　金：陕西省省科学技术厅重点项目(2020NY-035);西安市科技计划项目(创新能力强基计划)(22YXYJ0036);西安市科学技术局项目[201806115YF03NC11(1)];西安市卫健委科研人才项目(2022yb19);陕西省第一期兽医现场流行病学培训项目(SN-FETPV)。

摘　　要：为对羊布鲁氏菌病(简称布病)传播相关生物安全风险因素及其真实群流行率进行合并定量评价分析,从中英文数据库中筛选出符合条件的横断面研究及病例对照研究文献,使用二分类变量Meta分析定量评价羊布病传播风险因素,使用单组率Meta分析评价羊布病真实群体流行率,并进行文献敏感性分析。羊布病风险因素评价纳入5篇文献,从中筛选出8个风险因素,真实群流行率分析纳入8篇文献。分析认为:外购混养是最显著的羊布病传播风险因素(P<0.05),合并OR值为11.88,其次为1年内引进新羊(OR=4.80)、产羔地未消毒(OR=4.40)及共用/交换种公羊(OR=3.02),P值均<0.05;1年内有经纪人进羊圈(OR=4.21)、场区门口不消毒(OR=2.20)、流产母羊不处理或不进行治疗(OR=2.06)、与其他动物混养(OR=1.09)是影响羊布病传播的潜在风险因素(P>0.05)。北方地区羊布病真实群流行率为22%(95%CI:5%~39%),南方地区为0~3%(95%CI:0~6%),合并流行率为11%(95%CI:6%~17%)。提示应加强羊场生物安全风险管理,重点控制羊布病传播风险因素,关注潜在风险因素,加强羊只调运监管,采取针对性防控策略,推进畜间布病防控净化工作。In order to comprehensively and quantitatively evaluate biosafety risk factors related to ovine brucellosis transmission and its herd true prevalence(TP_(h)),articles on cross-sectional and case-control studies were selected from databases both in Chinese and English languages,the risk factors of ovine brucellosis transmission was quantitatively evaluated using dichotomous variable Meta-analysis,and the TP_(h) of ovine brucellosis was evaluated using single proportion Meta-analysis,followed by article sensitivity analysis.Five articles were included in the evaluation of ovine brucellosis risk factors,from which 8 risk factors were selected,and 8 articles were considered in the TP_(h).The most significant risk factor spreading brucellosis was mixed feeding with outsourced sheep,with a combined OR value of11.88,then were the sheep introduced within one-year(OR=4.80),non-disinfection on lambing premises(OR=4.40)and shared/exchanged stud rams(OR=3.02),P<0.05;and the potential risk factors(P>0.05)included brokers entering sheep pens within one year(OR=4.21),non-disinfection at entrance to the farm(OR=2.20),untreated aborted ewes(OR=2.06)and mixing with other animals(OR=1.09).The TP_(h) was 22%(95%CI:5%-39%)in northern region,and 0-3%(95%CI:0-6%)in southern region,the combined prevalence rate was 11%(95%CI:6%-17%).In conclusion,it was recommended to strengthen biosafety risk management on sheep farms with a priority to control of the risk factors of ovine brucellosis transmission and concern about potential risk factors,to improve supervision over sheep transportation,to implement targeted prevention and control strategies,and to facilitate prevention and purification of B rucello sis among animals.

关 键 词：布鲁氏菌病 风险因素 生物安全 META分析 羊 

分 类 号：S851.3[农业科学—预防兽医学]