塞内卡病毒的基因组结构与功能及其关键毒力因子  

Genomic Structure,Functions and Critical Virulence Factors of Senecavirus A

作　　者：李倩 刘枢清 赵艳薇 王迁迁 Li Qian;Liu Shuqing;Zhao Yanwei;Wang Qianqian(Zhenzhu Animal Husbandry and Veterinary Station,Laizhou 261400,Shandong,China;Qingdao Center for Animal Disease Control&Prevention,Qingdao 266199,Shandong,China;College of Veterinary Medicine,Qingdao Agricultural University,Qingdao 266109,Shandong,China)

机构地区：[1]莱州市珍珠畜牧兽医站,山东莱州261400 [2]青岛市动物疫病预防控制中心,山东青岛266199 [3]青岛农业大学动物医学院,山东青岛266109

出　　处：《中国动物检疫》2024年第11期106-110,共5页China Animal Health Inspection

基　　金：国家级大学生创新创业训练计划项目(202310435039)。

摘　　要：塞内卡病毒(Senecavirus A,SVA)是一种影响猪的重要病原体,其基因组变异对病毒进化和致病性密切相关。本文系统梳理了SVA的基因组结构、编码蛋白功能、基因变异类型,综述了影响SVA毒力的关键基因区域,包括结构蛋白编码基因、非结构蛋白编码基因以及非编码区,通过全面回顾SVA基因组研究进展,以期为深入了解SVA的分子流行病学特征提供基础,并为未来的疫病预防和控制提供依据。Senecavirus A(SVA)is an important pathogen affecting pigs,and its evolution and pathogenicity are closely related to its genomic variation.Here,its genomic structure,coding protein functions and types of gene variation were summarized,critical gene regions including structural and non-structural protein coding genes and noncoding region that might affect its virulence were described,and research progress on its genome was reviewed to provide a basis for further understanding its molecular epidemiological features and for future prevention and control of relevantdiseases.

关 键 词：塞内卡病毒 基因组结构 蛋白功能 毒力基因 

分 类 号：S852.65[农业科学—基础兽医学]