阿布昔替尼治疗局限性硬皮病  

Localized scleroderma successfully treated with abrocitinib:a case report

作　　者：申杰 赵国伟[1] SHEN Jie;ZHAO Guowei(Department of Dermatology,Zibo Central Hospital,Zibo 255000,China)

机构地区：[1]淄博市中心医院皮肤科,山东淄博255000

出　　处：《临床皮肤科杂志》2024年第12期734-736,共3页Journal of Clinical Dermatology

摘　　要：报告1例阿布昔替尼治疗局限性硬皮病。患者男,81岁。下腹部斑疹2年。皮肤科检查:下腹部多发大小不一褐色斑片,边界模糊,皮肤质硬呈皮革状,不易捏起。皮损组织病理:表皮大致正常,基底层黑素颗粒增加,真皮全层胶原纤维粗大变性,部分均质化,附属器缺失,真皮浅中层血管周围淋巴细胞及少量浆细胞浸润。诊断:局限性硬皮病。治疗:阿布昔替尼100 mg口服,每日1次,治疗2个月后腰腹部斑疹较前明显消退,皮肤质地变软。A case of abrocitinib in the treatment of localized scleroderma is reported.The patient was an 81-year-old male,with lower abdominal rash for two years.Dermatological examination showed multiple brown spots of different sizes in the lower abdomen,blurred boundaries,skin texture hard leathery,not easy to pinch.Histopathological examination of skin lesions showed that the epidermis was generally normal,the basal layer melanin particles increased,the whole dermal collagen fibers were coarse and denatalized,the accessory organs were missing,and perivascular lymphocytes and a small amount of plasma cells infiltrated in the superficial middle layer of the dermis.A diagnosis of localized scleroderma was made.After 2 months of treatment with oral abrocitinib(100 mg qd),dark erythema and pigmentation spots in the abdomen of the patient significantly subsided,and the skin texture became softer.

关 键 词：硬皮病 阿布昔替尼 JANUS激酶 

分 类 号：R593.25[医药卫生—内科学]