2型糖尿病患者血清SUMO1水平与高甘油三酯血症相关性研究  

Correlation between serum SUMO1 level and hypertriglyceridemia in type 2 diabetes mellitus patients

作　　者：张新燕 李涵 冉慧[1] 苏青[1] 张洪梅[1] ZHANG Xinyan;LI Han;RAN Hui;SU Qing;ZHANG Hongmei(Department of Endocrinology,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)

机构地区：[1]上海交通大学医学院附属新华医院内分泌科,上海200092

出　　处：《上海交通大学学报（医学版）》2024年第10期1266-1272,共7页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海市浦江人才计划(2019PJD033);国家自然科学基金(82100848)。

摘　　要：目的·探究2型糖尿病(type 2 diabetes mellitus,T2DM)患者血清小泛素样修饰分子1(small ubiquitin-like modifier-1,SUMO1)水平与高甘油三酯血症(hypertriglyceridemia,HTG)之间的相关性。方法·选取2020年9月至2021年3月在上海交通大学医学院附属新华医院内分泌科门诊就诊的新诊断为2型糖尿病的患者共239例,其中T2DM合并HTG组患者92例,T2DM不合并HTG组患者147例。收集患者基本信息和实验室指标,分析2组患者血清SUMO1水平的差异。采用二元Logistic回归分析T2DM合并HTG的影响因素,采用多元线性逐步回归分析血清SUMO1水平对T2DM合并HTG风险的影响。结果·与T2DM不合并HTG的患者相比,T2DM合并HTG患者的血清SUMO1水平明显升高(1114.99 pg/mL vs 902.43 pg/mL,P<0.001)。二元Logistic回归分析提示血清SUMO1水平(OR=1.527,95%CI 1.200~1.943)、糖化血红蛋白(OR=1.202,95%CI 1.038~1.391)、血尿酸(OR=1.006,95%CI 1.003~1.010)是T2DM合并HTG的独立危险因素。将血清SUMO1水平按照四分位分层,校正各种混杂因素后,以Q1层作为对照,Q4层T2DM合并HTG的风险是Q1层的2.707倍(95%CI 1.231~5.951)。多元线性逐步回归分析发现女性、腰臀比、甘油三酯、血肌酐是血清SUMO1水平升高的独立危险因素。结论·T2DM合并HTG患者血清SUMO1水平显著高于不合并HTG患者,血清SUMO1水平是T2DM合并HTG的独立危险因素。Objective·To explore the correlation between serum small ubiquitin-like modifier 1(SUMO1)levels and hypertriglyceridemia in patients with type 2 diabetes mellitus(T2DM).Methods·A total of 239 newly diagnosed T2DM patients were recruited from the endocrinology clinic of Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,between September 2020 and March 2021.Among them,92 patients had hypertriglyceridemia,and 147 patients did not.Basic information and laboratory parameters were collected.The differences in serum SUMO1 levels between the two groups were analyzed.Factors influencing hypertriglyceridemia in patients with T2DM were analyzed,and the impact of serum SUMO1 levels on the risk of hypertriglyceridemia in T2DM patients was investigated.Results·Patients with T2DM and hypertriglyceridemia had significantly higher serum SUMO1 levels compared to those without hypertriglyceridemia(1114.99 pg/mL vs 902.43 pg/mL,P<0.001).Binary Logistic regression analysis suggested that serum SUMO1 levels(OR=1.527,95%CI 1.200‒1.943),glycated hemoglobin(OR=1.202,95%CI 1.038‒1.391),and blood uric acid(OR=1.006,95%CI 1.003‒1.010)were independent risk factors for hypertriglyceridemia in patients with T2DM.After adjusting for various confounding factors and stratifying serum SUMO1 levels into quartiles,the risk of hypertriglyceridemia in T2DM patients with the highest quartile(Q4)of serum SUMO1 levels was 2.707 times higher compared to those in the lowest quartile(Q1)(95%CI 1.231‒5.951).Multiple linear stepwise regression analysis revealed that female gender,waist-to-hip ratio,triglycerides and serum creatinine were independent risk factors for elevated serum SUMO1 levels.Conclusion·Serum SUMO1 level in patients with T2DM complicated with HTG is significantly higher than that in patients without HTG,and the serum SUMO1 level is an independent risk factor for T2DM complicated with HTG.

关 键 词：小泛素样修饰分子1 SUMO化修饰 高甘油三酯血症 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]