维生素D联合高剂量干扰素在重症手足口病患儿中的应用  

Application of vitamin D combined with high-dose interferon in children with severe hand-foot-mouth disease

作　　者：黄威 章子旭 余海静[3] HUANG Wei;ZHANG Zixu;YU Haijing(Dept.of Infection,Huanggang Central Hospital,Huanggang 438000,Hubei,China;Dept.of Infection,Shiyan Renmin Hospital,Shiyan 442000,Hubei,China;Dept.of Infectious Diseases,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China)

机构地区：[1]黄冈市中心医院感染科,湖北黄冈438000 [2]十堰市人民医院感染科,湖北十堰442000 [3]华中科技大学同济医学院附属同济医院感染科,湖北武汉430030

出　　处：《武汉大学学报（医学版）》2024年第11期1386-1390,共5页Medical Journal of Wuhan University

基　　金：湖北省自然科学基金资助项目(编号:2019CFB415)。

摘　　要：目的:探究维生素D联合高剂量干扰素在重症手足口病患儿中的应用效果。方法:以2020年5月—2023年1月黄冈市中心医院收治的80例重症手足口病患儿为研究对象,依据其入院先后顺序分为两组。对照组40例予以高剂量干扰素治疗,研究组40例在对照组基础上联合补充维生素D。比较两组皮疹、发热、抖动消退时间及疱疹愈合时间,对比两组治疗前后的肝功能及神经功能,评价两组的临床疗效及安全性。结果:研究组的皮疹、发热、抖动消退时间及疱疹愈合时间均短于对照组(P<0.05);治疗后,研究组患儿的血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、神经特异性烯醇化酶(NSE)及中枢神经特异蛋白(S-100β)水平均低于对照组(P<0.05);研究组的治疗总有效率为91.67%,较对照组的73.33%显著升高(P<0.05);两组不良反应比较差异不显著(P>0.05)。结论:对重症手足口病患儿应用维生素D联合高剂量干扰素治疗效果显著,能有效缓解患儿的临床症状,改善患儿的肝功能,保护其神经功能,且具有较高的安全性。Objective:To explore the application effect of vitamin D combined with high-dose interferon in children with severe hand-foot-mouth disease.Methods:Eighty children with severe hand-foot-mouth disease admitted to Huanggang Central Hospital from May 2020 to January 2023 were selected as the study subjects,and were divided into two groups according to their admission order.Forty cases in the control group were treated with high-dose interferon,and 40 cases in the study group were supplemented with vitamin D on the basis of high-dose interferon.Then we compared the time of rash,fever, jitter and herpes healing between the two groups, as well as the liver function and nerve functionbefore and after treatment, and evaluated the clinical efficacy and safety of the two groups. Results:The duration of rash, fever, jitter and herpes healing in the study group were shorter than those in thecontrol group (P<0. 05). After treatment, the levels of the serum alanine aminotransferase (ALT),aspartate aminotransferase (AST), nerve specific enolase (NSE) and central nerve specific protein(S-100β) of children in the study group were lower than those in the control group (P<0. 05). The totaleffective rate of treatment in the study group was 91. 67%, which was significantly higher than therate of 73. 33% in the control group (P<0. 05). There was no significant difference in adverse reactionsbetween the two groups (P>0. 05). Conclusion: The treatment effect of vitamin D combinedwith high-dose interferon on children with severe hand-foot-mouth disease is significant. It can effectivelyrelieve the clinical symptoms of children, improve the liver function of children, protect theirnervous function, and has high safety.

关 键 词：重症手足口病 维生素D 高剂量干扰素 临床症状 肝功能 神经功能 

分 类 号：R725[医药卫生—儿科]