Tailoring supramolecular antimicrobial peptides:from self-assembled nanoarchitectures to activities  

定制超分子抗菌肽:从自组装纳米结构到活性

作　　者：Saisai Wang Jian Wu Yuan Tian Shaobing Zhou 王赛赛;吴坚;田原;周绍兵

机构地区：[1]Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs,School of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China [2]Institute of Biomedical Engineering,College of Medicine,Southwest Jiaotong University,Chengdu 610031,China [3]Pingshan Translational Medicine Center,Shenzhen Bay Laboratory,Shenzhen 518118,China [4]Tianfu Jincheng Laboratory,Chengdu 610041,China

出　　处：《Science China Materials》2024年第12期3763-3779,共17页中国科学（材料科学）（英文版）

基　　金：supported by the Natural Science Foundation of China(52033007 and U22A20161);the National Postdoctoral Program for Innovative Talents(BX20180264);China Postdoctoral Science Foundation(2018M643519);Sichuan Science and Technology Program(2023JDRC0028);Chengdu Science and Technology Project(2022-YF05-01966-SN);Shenzhen High-tech Zone Development Special Plan Pingshan District Innovation Platform Construction Project(29853MKCJ202300208);the Frontiers Medical Center,Tianfu Jincheng Laboratory Foundation(TFJC2023010008);the Fundamental Research Funds for the Central Universities(2682023ZTPY045).

摘　　要：The emergence of antibiotic-resistant bacteria has become a major threat to global public health and has prompted the discovery of antibiotic alternatives.Natural antimicrobial peptides(AMPs)confer a unique non-specific membrane rupture mechanism,showing great potential in killing drug-resistant bacteria.However,natural AMPs have certain weaknesses,including stability and toxicity issues,which seriously hinder their in vivo applications.Synthetic AMPs possess similar characteristics to natural AMPs,including positive charges,amphiphilicity,and the ability to fold into diverse secondary structures.These properties are essential for AMPs penetration into membranes,allowing them to exhibit antimicrobial effects.Moreover,supramolecular self-assembly,facilitated by hydrophobic interaction,hydrogen bonding,π-πstacking,and electrostatic interaction,can generate nanoparticles,nanotubes,nanofibers,and hydrogels with well-defined nanoarchitectures.Utilizing peptide self-assembly to form various nanoarchitectures is an effective approach for generating antibacterial nanomaterials,offering potential advantages such as enhanced antibacterial properties,improved stability,and reduced cytotoxicity.This review highlights recent advancements in tailoring supramolecular AMPs to create diverse nano-architectures for combating infectious diseases.耐药菌的产生已成为全球重大公共卫生问题,并促使人们探索抗生素的替代疗法.利用超分子多肽自组装形成抗菌纳米材料,在治疗耐药菌感染中显示出巨大潜力.本综述重点介绍了近年来通过定制超分子抗菌肽以构筑具有不同自组装纳米结构的抗菌材料,从自组装过程中的驱动力,如疏水作用、氢键、静电作用和π–π堆积等,到所形成的具有不同形貌和尺寸的纳米颗粒、纳米管、纳米纤维和水凝胶等纳米结构及其抗菌活性.最后讨论了超分子自组装抗菌肽所面临的挑战,并展望了未来的发展前景.

关 键 词：peptide self-assembly NANOARCHITECTURES antimicrobial activity antimicrobial peptides multidrug-resistant bacteria 

分 类 号：O641.3[理学—物理化学] TB383.1[理学—化学]