Tannic acid-based metal-phenolic networks as a versatile platform to mediate cell therapy  

基于单宁酸的金属-多酚网络介导细胞治疗的多功能平台

作　　者：Huilong Luo Juan Xie Xuechun Su Panpan Wang Huan Chen Xiao Kuang Jinyao Liu 罗会龙;谢娟;苏雪纯;王盼盼;陈焕;匡晓;刘尽尧

机构地区：[1]College of Chemistry and Materials Science,Shanghai Normal University,Shanghai 200234,China [2]Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine,Institute of Molecular Medicine,State Key Laboratory of Systems Medicine for Cancer,Shanghai Cancer Institute,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China

出　　处：《Science China Materials》2024年第12期3833-3848,共16页中国科学（材料科学）（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(22425505,82204503,22305152,and 22407089);the Explorer Program of the Science and Technology Commission of Shanghai Municipality(21TS1400400);the Two-hundred Talent(20181704)。

摘　　要：Surface modification using biomaterials is crucial for constructing bioactive interfaces that can control cell behavior,regulate biological processes,and interact with specific biomolecules.Tannic acid(TA),a naturally derived polyphenol,is of particular interest due to its ability to complex ions,facilitating the fabrication of coordination networks through self-assembly of TA and metal ions,known as metal-phenolic networks(MPNs).These MPNs can form stable,yet dynamic structures that can be further engineered or tailored for specific therapeutic needs.Synthetic TA-based MPN complexes have been constructed to modify diverse biointerfaces due to their unique physiochemical properties,including universal adhesion,pH responsiveness,controllable size and stiffness,ease of preparation,and excellent biocompatibility,which are highly advantageous for various biological applications,particularly in cell therapy.This review explores the synthesis,properties,and applications of TA-based MPNs in the context of therapeutic cells,including bacteria,yeast,and mammalian cells.Key aspects such as biocompatibility,biodegradability,the ability to modulate cellular environments,and clinical translation are discussed,highlighting the potential of TA-based MPNs to advance cell therapy.利用生物材料进行表面改性对于构建能够控制细胞行为、调节生物过程并与特定生物分子相互作用的生物活性界面至关重要.单宁酸(tannic acid,TA),作为一种能够与离子络合的天然多酚化合物,其可以与金属离子自组装而形成一种配位网络,即金属-多酚网络(metalphenolic networks,MPN),因而备受关注.这些金属-多酚网络不仅能形成稳定的动态结构,还可根据特定治疗需求进行工程化设计.由于其独特的理化性质,包括优良的粘附性、pH响应性、可控尺寸和刚度、易于制备以及良好的生物相容性,合成的基于单宁酸的金属-多酚结构已被广泛应用于修饰各种生物界面.这对于各种生物应用,特别是在细胞治疗中,具有极大的优势.本文探讨了基于单宁酸的金属-多酚网络在治疗性细胞(包括细菌、酵母和哺乳动物细胞)背景下的合成、性质与应用,重点阐述了其在生物相容性、可降解性、调节细胞环境能力及临床转化等方面的优势,强调了基于单宁酸的金属-多酚网络在推动细胞疗法方面的潜力.

关 键 词：tannic acid POLYPHENOLS metal-phenolic networks interface engineering cell therapy 

分 类 号：R318.08[医药卫生—生物医学工程]