Enhancing control over the degradation behavior of zinc alloy via MOF coating  

MOF涂层可控改性锌合金的降解行为

作　　者：Rongsheng Deng Yu Peng Qing Meng Zichun Jiang Qinglin Fang Yingzhi Chen Tong Li Kuo Men Bailiang Wang Luning Wang 邓荣胜;彭宇;孟晴;姜紫春;房庆霖;陈颖芝;李彤;门阔;王佰亮;王鲁宁

机构地区：[1]School of Materials Science and Engineering,University of Science and Technology Beijing,Beijing 100083,China [2]Shunde Graduate School of Science and Technology Beijing,Foshan 528399,China [3]Department of Orthopedics,China-Japan Friendship Hospital,Beijing 100029,China [4]State Key Laboratory of Advanced Materials for Smart Sensing,GRINM Group Co.,Ltd.,Beijing 100088,China [5]GRIMAT Engineering Institute Co.,Ltd.,Beijing 101402,China

出　　处：《Science China Materials》2024年第12期4074-4086,共13页中国科学（材料科学）（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(52371248,52373273);National Key R&D Program of China(2021YFB3802200);Guangdong Basic and Applied Basic Research Foundation(2023A1515010905);Fundamental Research Funds for the Central Universities(FRF-EYIT-23-05)。

摘　　要：Zinc and its alloys provide a scalable alternative to the list of biodegradable metals due to its moderate degradation rates and biocompatible degradation products.However,one of the challenges impeding their clinical applications is the uncontrollable and unstable interfacial reactions between zinc implants and the corrosive media.In this study,we report a facile synthesis of metal-organic framework(MOF)nanocrystal coating with tunable thickness on the high-strength Zn-0.8Li alloy matrix for controlled corrosion.The as-obtained dense and uniform MOF nanocrystals form a strong connection with the zinc matrix via coordination bond so as to maintain the mechanical properties,and meantime provide highly rough surfaces exhibiting tunable wettability.The varied MOF coating thus regulate the interface structure between the zinc matrix and corrosive media to control the degradation behavior.Excellent antibacterial activity and biocompatibility are also achieved because of the unique topology morphologies,surface superhydrophilicity,as well as the dynamic Zn^(2+)release.This study sheds valuable lights on the design of MOF-functionalized metal implants for practical use and also triggers extensive applications of MOF in biomaterials.锌及其合金由于其具有适中的降解率和生物相容性降解产物,为生物可降解金属提供了一种可拓展的替代品.然而,阻碍其临床应用的挑战之一是锌植入物与腐蚀性介质之间不可控和不稳定的界面反应.在这项研究中,我们报道了一种在高强度Zn-0.8Li合金基体上以厚度可调的金属有机框架(MOF)纳米晶涂层的简单合成,以控制腐蚀.所得到的致密均匀的MOF纳米晶通过配位键与锌基体形成紧密连接,从而保持其力学性能,同时提供了具有可调控润湿性的高粗糙表面.因此,不同的MOF涂层调节了锌基体与腐蚀性介质之间的界面结构,以控制其降解行为.由于独特的拓扑形态、超亲水性表面以及动态的Zn^(2+)释放,还具有优异的抗菌活性和生物相容性.这项研究为MOF功能化金属植入物的实际应用设计提供了宝贵的启示,也引发了MOF在生物材料中的广泛应用.

关 键 词：zinc alloy kinetic control DEGRADATION CYTOCOMPATIBILITY MOF coating 

分 类 号：TG146.13[一般工业技术—材料科学与工程] TG174.4[金属学及工艺—金属材料]