中医药诱导铁死亡治疗消化系统肿瘤的研究现状  

Research status of raditional Chinese medicine-induced ferroptosis for digestive system tumors

作　　者：李未鹏 林风池 封龙飞 王涛[2] 郭欢[2] 苏海翔 LI Wei-peng;LIN Feng-chi;FENG Long-fei;WANG Tao;GUO Huan;SU Hai-xiang(School of Basic Medical Sciences,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;Translational Medicine Research Center,Gansu ProvincialAl cademic Institute for Medical Research,Gansu Hospital,Affiliated Cancer Hospital of Sun Yat-sen University,Lanzhou 730050,Gansu Province,China)

机构地区：[1]甘肃中医药大学基础医学院,甘肃兰州730000 [2]甘肃省医学科学研究院、中山大学附属肿瘤医院甘肃医院转化医学研究中心,甘肃兰州730050

出　　处：《中国临床药理学杂志》2024年第22期3338-3342,共5页The Chinese Journal of Clinical Pharmacology

基　　金：甘肃省科技计划基金资助项目(18JR2FA010,23JRRA1254);兰州市科技计划基金资助项目(2023-4-56,2022-3-39);兰州市科技发展计划基金资助项目(2018-1-122)。

摘　　要：传统中医药与现代医学的手术、化疗、放疗等治疗手段相互配合,在消化系统肿瘤治疗中发挥了越来越重要的作用。中医药治疗消化系统肿瘤的机制涉及很多方面,其中一个重要的机制是诱导肿瘤细胞发生程序性死亡。铁死亡与二价铁和酯氧合酶催化的细胞膜上大量脂质过氧化物产生引起细胞死亡有关,与细胞氧化应激密切相关。本文对中医药通过诱导消化系统肿瘤细胞铁死亡发挥抗肿瘤作用的机制研究进行综述,以期为更好地开发利用中医药治疗消化系统肿瘤提供新思路。Traditional Chinese medicine combinedwith modern medicine,such as surgery,chemotherapy,radiotherapy and others,play an increasingly important role in the treatment of digestive system cancers.The research on the therapeutic mechanism of traditional Chinese medicine for digestive system tumors involves many aspects.One of these mechanism is that traditional Chinese medicine caninducethe programmed cell death of cancer cells.Programmed cell death includes apoptosis,programmed necrosis,pyroptosis and ferroptosis.Ferroptosis is closely related to the cell death caused by the production of lipid peroxides which are catalyzed over ferric divalent and ester oxygenase on the cell membrane and the cell oxidative stress.In order to provide the new ideas for better development and utilization of traditional Chinese medicine in the treatment of digestive system cancers,this paper reviews the research progress on the anti-cancer mechanism of traditional Chinese medicine through inducing the cancer cell ferroptosis.

关 键 词：中医药 消化系统 肿瘤 氧化应激 铁死亡 

分 类 号：R28[医药卫生—中药学]