小剂量多巴胺联合多巴酚丁胺治疗老年重症肺炎的效果  

Effect of Low-dose Dopamine Combined with Dobutamine in the Treatment of Severe Pneumonia in the Elderly

作　　者：尹华云 杨靖靖 卢韵弘 袁鑫[1] YIN Huayun;YANG Jingjing;LU Yunhong;YUAN Xin(Department of Critical Care Medicine,Airport Hospital,Tianjin Medical University General Hospital,Tianjin 300000,China)

机构地区：[1]天津医科大学总医院空港医院重症医学科,天津300000

出　　处：《中国药物滥用防治杂志》2024年第11期2072-2073,2098,共3页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨老年重症肺炎患者采取小剂量多巴胺联合多巴酚丁胺治疗的效果。方法:回顾性选择2018年5月—2023年5月天津医科大学总医院空港医院收治的老年重症肺炎患者86例进行研究,按照治疗方式不同分为对照组和观察组,各43例。对照组采取常规治疗,观察组采取小剂量多巴胺联合多巴酚丁胺治疗,比较两组治疗效果、症状改善时间、呼吸功能及不良反应发生呛咳。结果:观察组治疗有效率为95.35%,高于对照组的76.74%(P<0.05)。观察组发热缓解时间、咳痰缓解时间、呼吸困难缓解时间、胸部影像吸收时间、住院时间短于对照组(P<0.05)。观察组治疗后PIP、Raw、Wob低于对照组,Cdyn高于对照组(P<0.05);观察组与对照组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规治疗基础上给予小剂量多巴胺联合多巴酚丁胺治疗老年重症肺炎患者的效果良好,可促进症状快速消退,恢复正常呼吸功能及血气指标,具有良好的疗效和药物安全性。Objective:To investigate the effect of low-dose dopamine combined with dobutamine on elderly patients with severe pneumonia.Methods:A total of 86elderly patients with severe pneumonia admitted to Tianjin Medical University General Hospital Airport Hospital from May 2018 to May 2023 were retrospectively selected for the study.According to different treatment methods,they were divided into the control group and the observation group,with 43 patients in each group.The control group was treated with routine treatment,and the observation group was treated with low-dose dopamine combined with dobutamine.The therapeutic effect,symptom improvement time,respiratory function and adverse reactions of cough were compared between the two groups.Results:The effective rate of treatment in the observation group was 95.35%,which was higher than 76.74% in the control group(P<0.05).The fever relief time,expectoration relief time,dyspnea relief time,chest image absorption time and hospitalization time in the observation group were shorter than those in the control group(P<0.05).After treatment,PIP,Raw and Wob in the observation group were lower than those in the control group,and Cdyn was higher than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion:On the basis of routine treatment,low-dose dopamine combined with dobutamine is effective in the treatment of elderly patients with severe pneumonia,which can promote the rapid regression of symptoms,restore normal respiratory function and blood gas indexes,and has good efficacy and drug safety.

关 键 词：重症肺炎 多巴胺 多巴酚丁胺 呼吸功能 不良反应 

分 类 号：R563.1[医药卫生—呼吸系统]