利多卡因凝胶贴膏辅助治疗带状疱疹后遗神经痛的效果  

Effect of Lidocaine Gel Plaster in Adjuvant Treatment of Postherpetic Neuralgia

作　　者：顾建新[1] 刘光杰 GU Jjanxin;LIU Guangjie(Department of Anesthesiology,Tianjin Baodi District Haibin Hospital,Tianjin 301800,China;Department of Pharmacy,Hexiwu Hospital,Wuqing District,Tianjin 301714,China)

机构地区：[1]天津市宝坻区海滨医院麻醉科,天津301800 [2]天津市武清区河西务医院药剂科,天津301714

出　　处：《中国药物滥用防治杂志》2024年第11期2077-2078,2091,共3页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:研究利多卡因凝胶贴膏联合神经阻滞、臭氧局部注射治疗带状疱疹后遗神经痛的效果。方法:选择2021年1月—2022年12月我院收治的80例带状疱疹后遗神经痛患者,随机分为对照组和观察组,每组40例。对照组采用神经阻滞、臭氧局部注射治疗,观察组采用利多卡因凝胶贴膏联合神经阻滞、臭氧局部注射治疗。比较两组生活质量评分及实验室指标[神经肽Y(NPY)、β-内啡肽(β-EP)、P物质(SP)、白细胞介素(IL)-1β、肿瘤坏死因子-α(TNF-α)、IL-10和IL-6]。结果:治疗后,观察组生活质量各维度评分低于对照组(P<0.05);观察组血清NPY、β-EP、SP、IL-1β、TNF-α、IL-10和IL-6水平均优于对照组(P<0.05)。结论:带状疱疹后遗神经痛患者使用利多卡因凝胶贴膏联合神经阻滞、臭氧局部注射治疗效果较佳,可改善疼痛相关神经肽水平及炎症因子水平,进而提升患者生活质量。Objective:To study the effect of lidocaine gel plaster combined with nerve block and ozone local injection in the treatment of postherpetic neuralgia.Methods:A total of 80 patients with postherpetic neuralgia admitted to our hospital from January 2021 to December 2022 were randomly divided into control group and observation group,with 40 patients in each group.The control group was treated with nerve block and local injection of ozone,while the observation group was treated with lidocaine gel plaster combined with nerve block and local injection of ozone.The quality of life scores and laboratory indexes[neuropeptide Y(NPY),β-endorphin(β-EP),substance P(SP),interleukin(IL)-1β,tumor necrosis factor-α(TNF-α),IL-10 and IL-6]were compared between the two groups.Results:After treatment,the scores of various dimensions of quality of life in the observation group were lower than those in the control group(P<0.05);the serum levels of NPY,β-EP,SP,IL-1β,TNF-α,IL-10,and IL-6 in the observation group were better than those in the control group(P<0.05).Conclusion:Lidocaine gel plaster combined with nerve block and ozone local injection is effective in the treatment of patients with postherpetic neuralgia,which can improve the level of pain-related neuropeptides and inflammatory factors,and then improve the quality of life of patients.

关 键 词：利多卡因凝胶贴膏 神经阻滞 臭氧局部注射 带状疱疹后遗神经痛 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]