复方黄柏液涂剂联合甲硝唑凝胶治疗细菌性阴道炎的临床疗效  

Efficacy and safety of compound Huangbai liquid coating agent combined with metronidazole gel in the treatment of bacterial vaginitis

作　　者：韩知言 王颖 杨雪 刘冰洁 孔庆军 HAN Zhiyan;WANG Ying;YANG Xue;LIU Bingjie;KONG Qingjun(Health Department,PLA Eastern Theater General Hospital,Nanjing210000,China)

机构地区：[1]中国人民解放军东部战区总医院保健科,南京210000

出　　处：《中国临床药学杂志》2024年第10期761-764,共4页Chinese Journal of Clinical Pharmacy

摘　　要：目的探讨复方黄柏液涂剂联合甲硝唑凝胶治疗细菌性阴道炎的临床效果。方法选择2022年1月至2023年1月我院收治的细菌性阴道炎患者120例,采用随机数字表法分成对照组与观察组,每组60例。对照组采取甲硝唑凝胶适量阴道内给药治疗,观察组采取甲硝唑凝胶适量阴道内给药联合复方黄柏液涂剂坐浴治疗,疗程均为7 d。疗程结束后检测并比较2组阴道菌群多样性、菌群密集度、阴道pH值及性激素水平,并评估2组临床疗效及安全性。结果观察组治疗总有效率显著高于对照组(98.33%vs88.33%,P<0.05)。观察组阴道pH值、菌群多样性及菌群密集度显著优于对照组(P<0.05)。2组治疗后睾酮、孕酮及雌二醇水平均显著高于治疗前(P<0.05),且观察组显著高于对照组(P<0.05)。2组均未见不良反应发生。结论复方黄柏液涂剂联合甲硝唑凝胶治疗细菌性阴道炎的疗效好,安全性较高,可有效提高患者性激素水平及改善阴道酸碱环境。AIM To explore the clinical effect of compound Huangbai liquid coating agent combined with metronidazole gel in the treatment of bacterial vaginitis.METHODS A total of 120 patients diagnosed with bacterial vaginitis at our hospital from January 2022 to January 2023 were divided into control group and observation group by random number table method,with 60 patients in each group.The control group was treated with vaginal administration of metronidazole gel,while the observation group was treated with vaginal administration of metronidazole gel combined with compound Huangbai liquid coating agent in sitz bath,with a course of 7 days.After the course of treatment,the vaginal flora diversity,flora density,vaginal pH value and sex hormone level of 2 groups were detected and compared,and the clinical efficacy and safety of 2 groups were evaluated.RESULTS The total effective rate in the observation group was significantly higher than that in the control group(98.33%vs 88.33%,P<0.05).The vaginal pH value,flora diversity and flora density in the observation group were significantly better than those in the control group(P<0.05).The levels of testosterone,progesterone and estradiol in 2 groups were significantly higher after treatment(P<0.05),and levels in the observation group were significantly higher than those in the control group(P<0.05).There were no adverse drug reactions in both groups.CONCLUSION Compound Huangbai liquid coating agent combined with metronidazole gel is effective and safe in the treatment of bacterial vaginitis,which can effectively increase the level of sex hormones and improve the acid-base environment of vagina.

关 键 词：复方黄柏液涂剂 甲硝唑凝胶 细菌性阴道炎 菌群密集度 菌群多样性 性激素 

分 类 号：R711.31[医药卫生—妇产科学]