静注右美托咪定、利多卡因对腹腔镜疝修补术患者围手术期心率、麻醉苏醒质量的比较  

Comparison of intravenous injection of dexmedetomidine and lidocaine on perioperative heart rate and anesthesia recovery quality in patient undergoing laparoscopic hernia repair

作　　者：张锋 孙孟奇 方秀春 Feng Zhang;Mengqi Sun;Xiuchun Fang(Department of Anesthesiology,Funan County People's Hospital,Fuyang 236300,Anhui Province,China)

机构地区：[1]阜南县人民医院麻醉科,安徽阜阳236300

出　　处：《中华疝和腹壁外科杂志（电子版）》2024年第5期562-565,共4页Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition)

基　　金：阜阳市卫生健康委科研项目(FY2021-122)。

摘　　要：目的比较静注右美托咪定(Dex)、利多卡因(Lido)对腹腔镜疝修补术患者围手术期心率(HR)、麻醉苏醒质量。方法选取在2021年1月至2023年8月阜南县人民医院收治的80例腹腔镜疝修补术患者,按随机数表法分为Dex组(静注Dex)和Lido组(静注Lido)。比较2组患者围手术期HR及平均动脉压(MAP),术中平均七氟醚吸入浓度、拔管时间、苏醒时间、躁动发生率、躁动持续时间、药物补救次数及镇痛评分。比较2组术前及术后即刻疼痛应激生化指标,记录2组不良反应发生情况。结果2组围手术期HR和MAP组间、时间点及交互差异均无统计学意义(P>0.05);Lido组术中平均七氟醚吸入浓度、拔管时间、苏醒时间均低于Dex组(P<0.05);2组躁动发生率、躁动持续时间、药物补救次数比较差异无统计学意义(P>0.05);2组在术后3、12和24 h镇痛评分比较差异无统计学意义(P>0.05);与术前相比,术后即刻2组血清超氧化物歧化酶(SOD)均降低(P<0.05)、丙二醛(MDA)均升高(P<0.05),但2组SOD和MDA比较,差异无统计学意义(P>0.05);2组不良反应发生情况比较,差异无统计学意义(P>0.05)。结论静注Dex和Lido对腹腔镜疝修补术患者均有较佳麻醉效果,血流动力学稳定,但Lido可以缩短拔管时间,患者苏醒更快,更利于术后恢复。Objective To compare the effect of intravenous injection of dexmedetomidine(Dex)and lidocaine(Lido)on perioperative heart rate(HR)and anesthesia recovery quality in patient undergoing laparoscopic hernia repair.Methods Eighty patients undergoing laparoscopic hernia repair from January 2021 to August 2023 were selected and randomly divided into Dex group(intravenous injection of Dex)and Lido group(intravenous injection of Lido)according to random number table method.The perioperative HR,mean arterial pressure(MAP),intraoperative mean sevoflurane inhalation concentration,extubation time,recovery time,incidence rate of agitation,duration of agitation,number of drug remedy,and analgesia score were compared between the two groups.The pain stress biochemical indicators before and immediately after surgery were compared between the two groups,and the occurrence of adverse reactions were recorded.Results There were no statistically significant differences in perioperative HR and MAP from the aspects of between groups,time points and interaction(P>0.05).Compared with the Dex group,the Lido group had significantly lower intraoperative sevoflurane concentration,shorter extubation time and recovery time(P<0.05).There was no significant difference in the incidence rate of agitation,duration of agitation,number of drug remedy between the two groups(P>0.05).There was no significant significance in analgesia score between the two groups at 3 hours,12 hours and 24 hours after surgery(P>0.05).Compared with before surgery,the serum superoxide dismutase(SOD)in both groups was decreased(P<0.05)while malondialdehyde(MDA)was increased(P<0.05),but the difference was not significant in SOD and MDA between the two groups(P>0.05).There was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusion Intravenous injection of Dex and Lido for patients undergoing laparoscopic hernia repair have good anesthesia effect and stable perioperative hemodynamics.However,Lido has shorter extubation time,and fa

关 键 词：右美托咪定 利多卡因 腹腔镜 疝修补术 苏醒质量 

分 类 号：R614[医药卫生—麻醉学] R656.2[医药卫生—外科学]