Advances and challenges of mpox detection technology  

作　　者：Wenjing Liu Erxin Zhang Wei Li Ruichen Lv Yanfeng Lin Yingjia Xu Jiameng Li Yuzhen Lai Yuxin Jiang Sijia Lin Xueqin Wang Peize Zhou Yue Song Wanpeng Shen Yiqian Sun Yuexi Li 

机构地区：[1]Nanjing Bioengineering(Gene)Technology Center for Medicines,Nanjing 210002,China [2]School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China [3]School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 211198,China [4]School of Life Science and Technology,China Pharmaceutical University,Nanjing 211198,China [5]School of Public Health,Nanjing Medical University,Nanjing 211100,China [6]School of Engineering,China Pharmaceutical University,Nanjing 211198,China

出　　处：《Biosafety and Health》2024年第5期260-269,共10页生物安全与健康（英文）

基　　金：financial support was received for the research,authorship,and/or publication of this article;funded by Nanjing Bioengineering(Gene)Technology Center for Medicines(2024YQFH01)。

摘　　要：Mpox is a zoonotic disease caused by the monkeypox virus(MPxV).Diagnosing and treating the disease has become a global health concern requiring close attention to its spread to non-endemic regions.Clinical diag-nosis is based on laboratory test results.Conventional detection techniques include real-time quantitative poly-merase chain reaction(qPCR),genome sequencing,antigen and antibody identification,and virus isolation.Nevertheless,these methods fall short of rapidly and efficiently identifying MPxV,as they require specialized training,specific laboratory environments,and professional-grade equipment.Emerging technologies offer complementary advantages to meet diverse diagnostic needs,including various point-of-care testing(POcT)approaches and integrating biosensors with rapid detection techniques.This review discusses prospective future research avenues for MpxV detection,examining the advances and challenges of various detection tech-niques which may contribute to the ongoing elimination of mpox human-to-human transmission and serves as a reference for developing effective prevention and control strategies.

关 键 词：Monkeypox virus(MPXV) Detection technology Point-of-care testing(POCT) BIOSENSOR 

分 类 号：R511[医药卫生—内科学] R446.5[医药卫生—临床医学]