An outbreak of rhinovirus infection in a primary school in Shenyang City,China,in 2022  

作　　者：Yage Wang Jiayuan Liang Zhibo Xie Bing Wang Jinhua Song Baicheng Xia Huiling Wang Yao Zhang Ye Chen Ling Chen Shi Cong Yu Liu Aili Cui Yan Zhang 

机构地区：[1]National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,NHC Key Laboratory of Medical Virology and Viral Diseases,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China [2]Liaoning Provincial Center for Disease Prevention and Control,Shenyang 110000,China [3]Shenyang Prefecture Center for Disease Control and Prevention,Shenyang 110031,China [4]Shenyang Medical Cllege,Shenyang 110034,China [5]Yuhong District Center for Disease Control and Prevention,Shenyang 110146,China

出　　处：《Biosafety and Health》2024年第5期298-303,共6页生物安全与健康（英文）

基　　金：supported by the National Key Research and Development Program of China(2022YFC2704904).

摘　　要：Rhinovirus(RV)is a common pathogen that causes respiratory tract infection and can cause outbreaks in hos-pitals and welfare institutions.A cluster of respiratory diseases occurred in a primary school in Shenyang City,Liaoning Province,China,in 2022.In this outbreak,a total of 31 students had symptoms similar to those of upper respiratory tract infection,mainly cough and sore throat.Among them,27 throat swabs were collected and identified for respiratory pathogens by TaqMan low-density array(TLDA),quantitative real-time poly-merase chain reaction(PCR),reverse transcription-nested PCR and whole-genome sequencing.Out of the 27 specimens,24 tested positive for RV,and 21 RV viral protein 1 sequences were obtained,of which 15(71.43%)were identified as RV-A49,while 2 RV-A20 and 4 sequences from 2 specimens were RV-A30 coin-fected with RV-C15.In addition,one whole-genome sequence(WGS)of RV-A49 was obtained,and three unique amino acid mutations were found compared to 23 WGS of RV-A49 from GenBank.In conclusion,this outbreak of upper respiratory tract infection is caused by RV,mainly RV-A49.

关 键 词：Rhinoviruses(RV) Rhinoviruses-A49 type OUTBREAK Primary school Respiratory tract infection 

分 类 号：R725.1[医药卫生—儿科]