父母亲本起源基因互作调控胚根干细胞龛分化  

Interaction of Parental-of-Origin Genes Regulates Root Stem Cell Niche Differentiation

作　　者：程天河 孙蒙祥[1] CHENG Tianhe;SUN Mengxiang(College of Life Sciences,Wuhan University,Wuhan 430072,China)

机构地区：[1]武汉大学生命科学学院,武汉430072

出　　处：《中国细胞生物学学报》2024年第11期1849-1854,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:32130031、31991201);中国博士后科学基金(批准号:2021M702524)资助的课题。

摘　　要：受精卵整合了父母亲本的遗传信息后启动胚胎发生。关于父母亲本对子代胚胎的贡献问题已讨论了数十年,已有的数据表明父母双方都参与调控了植物早期胚胎发生。遗憾的是,父本对胚胎发育的具体调控作用,以及相关的分子调控途径迄今仍知之甚少,对父母亲本基因如何相互作用更是不甚了解。武汉大学有性生殖团队最新研究揭示,TREE1和它的同源物DAZ3作为父本起源基因在受精卵中通过直接抑制母本起源基因RKD2的转录,解除RKD2对根干细胞龛分化的有害影响,从而确保胚胎正常发育和胚后根的正常发生。这一研究结果阐明了精子的遗传缺陷如何对特定植物器官分化施加持久的父本影响,以及父母亲本基因如何相互作用以确保正常的胚胎发生。这项工作还提出了植物器官形成的先天性调控的新途径。The fertilization integrates genetic information from both parents and initiates embryogenesis.The involvement of parental contributions in embryo development has been a hot topic for decades.Available data suggest that both parents play roles in early embryogenesis.However,the specific processes and associated molecular pathways involved in paternal contribution to early embryogenesis and plant development is poorly understood,not to mention how the parental-of-origin genes interaction.Recently,researchers from Wuhan University reveal that TREE1 and its homolog DAZ3 as paternal-of-origin genes can directly inhibit the transcription of a maternal-oforigin gene RKD2 in fertilized egg cell,so that counteract the RKD2 maternal detrimental effects to ensure normal embryogenesis and root organogenesis.These findings shed light on how genetic abnormalities in sperm can have long-lasting paternal effects on specific plant organ differentiation,as well as how interactions between parental-oforigin genes ensure normal embryogenesis.This work also introduces a new concept regarding how plant organogenesis can be influenced by gamete quality.

关 键 词：精细胞 卵细胞 受精作用 父母亲本起源基因 胚根原 根干细胞龛 拟南芥 

分 类 号：Q943[生物学—植物学]