PLAC与胎盘源性妊娠疾病关系的研究进展  

Advances in the Relationship between PLAC and Placenta-Mediated Pregnancy Disorders

作　　者：李连春 朱真仪 杨好 杨永康[2] 李勤[2] LI Lianchun;ZHU Zhenyi;YANG Hao;YANG Yongkang;LI Qin(Second Clinical Medical College,Shaanxi University of Chinese Medicine,Xianyang 712046,China;The Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China)

机构地区：[1]陕西中医药大学第二临床医学院,咸阳712046 [2]陕西中医药大学第二附属医院,咸阳712000

出　　处：《中国细胞生物学学报》2024年第11期1976-1984,共9页Chinese Journal of Cell Biology

基　　金：咸阳市重点研发计划(批准号:L2023-ZDYF-SF-050);陕西中医药大学研究生创新实践能力提升项目(批准号:CXSJ202328)资助的课题。

摘　　要：胎盘特异性家族蛋白(placenta-specific family protein,PLAC)是一类胎盘特异性表达的蛋白,主要通过调控胎盘的形成、胚胎的植入、滋养细胞和胚胎干细胞的功能,促进胎盘和胎儿的生长发育,确保妊娠的顺利进展。近年来,越来越多的关于PLAC在胎盘源性妊娠疾病中的表达变化备受关注,与健康孕妇之间存在显著差异,相关蛋白和基因表达异常可能与胎盘功能障碍和疾病发生风险相关。该文探讨PLAC与胎盘源性妊娠疾病关系和作用机制,其可能成为妊娠疾病的潜在生物标志物,有望用于疾病的诊断和预防。PLAC(placenta-specific family protein)is a class of placenta-specific expressed protein that promote placental and fetal growth and development,and ensure the smooth progression of pregnancy by regulating placental formation,embryo implantation,and the function of trophoblast and embryonic stem cells.In recent years,more and more attention has been paid to the changes in expression of PLAC family protein in placenta-mediated pregnancy disorders,with significant differences between them and healthy pregnant women,and abnormalities in the expression of related proteins and genes that may be associated with the risk of placental dysfunction and disease development.It is important to explore the relationship and mechanism of action of PLAC family protein with placenta-mediated pregnancy disorders,and they may be potential biomarkers for pregnancy disorders,which are expected to be used for diagnosis and prevention of diseases.

关 键 词：胎盘特异性蛋白 胎盘发育 滋养细胞 胎盘源性妊娠疾病 

分 类 号：R714.2[医药卫生—妇产科学]