生长因子与皮肤创伤愈合  

Growth Factors and Skin Wound Healing

作　　者：黄煜翔 何晓燕 HUANG Yuxiang;HE Xiaoyan(Tonghua Normal Nuiversity,School of Life Sciences,Tonghua 134100,China)

机构地区：[1]通化师范学院生命科学学院,通化134100

出　　处：《中国细胞生物学学报》2024年第11期1997-2008,共12页Chinese Journal of Cell Biology

摘　　要：皮肤创伤愈合是一种临床常见的病症,包括急性和慢性两种类型,伤口修复过程通常分为四个阶段:止血期、炎症期、细胞增殖分化期和组织重建期,各阶段的有序进行是伤口修复成功的关键。在伤口修复过程中,生长因子发挥了至关重要的作用,主要体现在调控血管再生,调控细胞增殖、迁移、分化,影响炎症与氧化应激,调控胶原蛋白的合成,调节基质的合成,调节疤痕的形成六个方面。目前,关于生长因子在皮肤创伤愈合中的综合作用研究较为有限,而且现有的临床治疗手段也相对匮乏,因此,探究生长因子与皮肤创伤愈合的联系,有助于寻找和分析新的有效治疗方案。该文采用图表归纳和文字分析的方法探讨了生长因子促进皮肤愈合的作用机制以及临床使用的伤口愈合类材料的优劣,旨在为今后皮肤创伤愈合相关研究及新型伤口愈合材料的开发提供一定的参考。Skin wound healing is a common clinical condition,including acute and chronic types.The wound repair process is usually divided into four phases:hemostasis,inflammation,cell proliferation and differentiation and tissue reconstruction,and the orderly conduct of each phase is the key to the success of wound repair.In the process of wound repair,growth factors play a crucial role,which is mainly reflected in six aspects:regulating vascular regeneration,regulating cell proliferation,migration and differentiation,influencing inflammation and oxidative stress,regulating collagen synthesis,regulating matrix synthesis,and regulating scar formation.Currently,research on the integrative role of growth factors in skin wound healing is relatively limited,and there is a relative paucity of available clinical treatments;therefore,exploring the link between growth factors and skin trauma healing can help to find and analyze new and effective therapeutic options.In this paper,the mechanism of action of growth factors in promoting skin healing and the advantages and disadvantages of clinically used wound healing materials are explored by means of graphical summarization and textual analysis,with the aim of providing certain references for future research related to skin wound healing and the development of new wound healing materials.

关 键 词：生长因子 信号通路 创伤愈合 创伤愈合手段 

分 类 号：R641[医药卫生—外科学]