Co-Catalyzed Dehydrogenation Claisen Condensation of Secondary Alcohols with Esters  

作　　者：Shuo Gao Wentao Hao Yuqi Ji Xiulin Li Chunyan Zhang Guoying Zhang 

机构地区：[1]State Key Laboratory of Coal Conversion,Institute of Coal Chemistry,Chinese Academy of Sciences,Taiyuan,Shanxi 030001,China [2]College of Ecology,Taiyuan University of Technology,Taiyuan,Shanxi 030001,China [3]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Chinese Journal of Chemistry》2024年第22期2818-2824,共7页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(22002067,22202228);the Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province(20220052);the Science and Technology Project of Shanxi Province(202103021223457,202303021221256);Research Project Supported by Shanxi Scholarship Council of China.

摘　　要：Catalytic dehydrogenation,with its exceptional atom economy and chemoselectivity,offers a highly desirable yet challenging approach for converting multiple environmentally friendly alcohols into crucial molecules.Furthermore,the utilization of catalysts based on abundant elements found on Earth for alcohol dehydrogenation to produce acryl ketone holds significant promise as a versatile strategy in synthesizing key building blocks for numerous pharmaceutical applications.The present study describes a practical Co-catalyzed cascade dehydrogenative Claisen condensation of secondary alcohols with esters,facilitating the synthesis of a wide range of 3-hydroxy-prop-2-en-1-ones.We introduce a catalytic system based on novel and scalable indazole NNP-ligands coordinated to cobalt for efficient dehydrogenations of secondary alcohols,and propose a plausible reaction mechanism supported by control experiments and labeling studies.Notably,it allows for the streamlined synthesis of multiple pharmaceuticals in one-pot.

关 键 词：Cobalt Pincer Ligand DEHYDROGENATION Claisen Condensation 3-Hydroxy-prop-2-en-1-one ALCOHOLS 3d transition metals ENOLS ENONES 

分 类 号：O62[理学—有机化学]