7323名公交驾驶员高尿酸血症患病现状调查及危险因素分析  

Prevalence and risk factors of hyperuricemia among 7323 bus drivers

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作  者:赵祖巧 曾家顺 潘科 马铭 赵俊文 ZHAO Zuqiao;CENG Jiashun;PAN Ke;MA Ming;ZHAO Junwen(Department of Rheumatology&Immunology,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China;Department of Gastroenterology People's Hospital of Qiannan,Qiannan 558000,Guizhou,China;Health Management Center,Guizhou Provincial Staff Hospital,Guiyang 550000,Guizhou,China)

机构地区:[1]贵州医科大学附属医院风湿免疫科,贵州贵阳550004 [2]黔南州人民医院消化内科,贵州黔南558000 [3]贵州省职工医院健康管理中心,贵州550000

出  处:《贵州医科大学学报》2024年第11期1645-1650,1686,共7页Journal of Guizhou Medical University

基  金:贵州省科技厅项目黔科(合基础-ZK[2023]一般397);贵州医科大学附属医院国家自然科学基金培育项目(I-2020-244);贵州省卫健委课题项目(gzwkj2021-133);贵州医科大学博士科研启动基金项目(gyfybsky-2021-62);贵州省中医药管理局(QZYY-2021-005);黔南民族医学高等专科学校科技骨干支撑项目(Qnyz2022027)。

摘  要:目的 了解贵阳市公交驾驶员高尿酸血症(HUA)的患病现状,分析该人群发生HUA的危险因素。方法 选取7 323名公交驾驶员,根据HUA水平分为HUA组与正常尿酸组(NUA组),比较两组公交驾驶员身高、血压及血液检查结果,对HUA影响因素进行单因素分析,将单因素分析中具有统计学意义的指标进行多因素Logistic回归分析。结果 7 323名驾驶员中2 455人诊断为HUA,患病率为33.52%,男性为37.00%,女性为8.42%;男性、低年龄段(20~29岁)、超重以及肥胖公交驾驶员的HUA患病率相对较高(P<0.05);HUA组公交驾驶员的身高、收缩压(SBP)、舒张压(DBP)、白细胞(WBC)、低密度脂蛋白胆固醇(LDL)、甘油三脂(TG)、总胆固醇(TC)、空腹血糖(FPG)、肌酐(Scr)、癌胚抗原(CEA)、谷丙转氨酶(ALT)、谷草转氨酶(AST)以及白蛋白(ALB)比NUA组高(P<0.05);单因素分析显示,男性、低年龄段(20~29岁)、女性≥50岁、超重和肥胖、WBC、高密度脂蛋白胆固醇(HDL)、LDL、TG、TC、FPG、Scr、CEA、ALT、AST以及ALB是公交驾驶员HUA发生的影响因素(P<0.05);多因素分析显示,男性、低年龄段(20~29岁)、女性≥50岁、超重、高WBC、血脂异常(低HDL、高LDL、高TG)、高FPG、高Scr、高ALT、高AST以及高ALB是HUA发生的独立危险因素(P<0.05)。结论 贵阳市公交驾驶员HUA患病率较高,低年龄段(20~29岁)、男性、女性≥50岁、超重、高WBC、血脂异常等是HUA发生的独立危险因素。Objective To investigate the prevalence of hyperuricemia(HUA)and identify risk factors among bus drivers in Guiyang.Methods A cross-sectional study of 7323 bus drivers,categorizing participants into HUA and normal uric acid(NUA)groups were conducted.Anthropometric measurements,blood pressure,and biochemical parameters were compared between groups.Univariate analysis identified potential risk factors,followed by multivariate logistic regression analysis of statistically significant variables.Results The overall prevalence of HUA was 33.52%(2,455/7,323),with rates of 37.00%in males and 8.42%in females.Higher prevalence rates were observed among males,young adults(20-29 years),and individuals with elevated body mass index(BMI,P<0.05).The HUA group demonstrated significantly higher values for height,systolic blood pressure(SBP),diastolic blood pressure(DBP),white blood cell(WBC),low density lipoprotein cholesterol(LDL),triglyceride(TG),total cholesterol(TC),fasting plasma glucose(FPG),serum creatinine(Scr),carcinoembryonic antigen(CEA),alanine aminotransferas(ALT),aspartate aminotransferase(AST),and albumin(ALB)compared to the NUA group(P<0.05).Univariate analysis showed that male,low age(20-29 years old),female≥50 years old,overweight,high WBC,increased high density lipoprotein cholesterol(HDL),LDL,TG,TC,FPG,Scr,CEA,ALT,AST,and ALB were the influencing factors of HUA in bus drivers(P<0.05).Multivariate analysis identified male gender,age 20-29 years,female age≥50 years,overweight status,elevated WBC,dyslipidemia(low HDL,high LDL,high TG),elevated FPG,high Scr,and increased liver function parameters(ALT,AST,ALB)as independent risk factors for HUA(P<0.05).Conclusion Bus drivers in Guiyang demonstrate a high prevalence of HUA.Young adult age,male gender,postmenopausal female status,overweight,elevated WBC,and metabolic abnormalities represent independent risk factors for HUA development.

关 键 词:公交驾驶员 高尿酸血症 患病现状 危险因素 

分 类 号:R181.3[医药卫生—流行病学]

 

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