中药复方对奶牛子宫内膜炎治疗效果及抗炎作用研究  

Study on the the rapeutic effect and anti-inflammatory action of traditional Chinese medicine on cow endometritis

作　　者：于亚明 邓翔文 武志勇 崔冀秦 李奎 施宗傲 刘振广 杨阳 赵海成 未钰杨 刘丽 王德云[1] YU Yaming;DENG Xiangwen;WU Zhiyong;CUI Jiqin;LI Kui;SHI Zongao;LIU Zhenguang;YANG Yang;ZHAO Haicheng;WEI Yuyang;LIU Li;WANG Deyun(College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,China;Jiangsu Research Institute of Chinese Veterinary Medicine,Nanjing 210018,China;Shijiazhuang Shimu Pharmaceutical Co.,Ltd.,Shijiazhuang 050227,China)

机构地区：[1]南京农业大学动物医学院,江苏南京210095 [2]江苏中兽医药研究院有限公司,江苏南京210018 [3]石家庄石牧药业有限公司,河北石家庄050227

出　　处：《畜牧与兽医》2024年第12期104-109,共6页Animal Husbandry & Veterinary Medicine

基　　金：国家重点研发计划项目(2022YFD1801103);中央高校基本科研业务费专项资金资助项目(KYCXJC2023003)。

摘　　要：为探究中药复方对奶牛子宫内膜炎的治疗效果及抗炎作用的影响,选择20头患子宫内膜炎奶牛,随机分为两组,每组10头,分别为中药复方组和阳性药物组。中药复方组奶牛每头每天灌服0.4 g/kg体重的中药复方,阳性药物组奶牛每头每天肌肉注射盐酸头孢噻呋注射液0.04 mL/kg,连续给药5 d,同时另选择10头健康奶牛,作为健康组,记录给药前及停药1 d后各组奶牛体温变化、子宫分泌物评分,以评价子宫内膜炎的治愈效果;检测奶牛子宫黏液、血清中炎性因子肿瘤坏死因子α(TNF-α)、白介素1β(IL-1β)、白介素6(IL-6)的水平以及血清生化指标,以评价中药复方的抗炎作用及安全性。结果:给药前与健康组相比,中药复方组与阳性药物组奶牛体温及子宫分泌物评分显著升高(P<0.05);停药1 d后,中药复方组与阳性药物组奶牛体温及子宫分泌物评分降低(P<0.05);停药1 d后,中药复方组和阳性药物组治愈率分别为70%和60%,有效率分别为10%和20%,总有效率均为80%;此外,给药前,中药复方组与阳性药物组奶牛子宫黏液及血清中TNF-α、IL-6、IL-1β的水平显著高于健康组(P<0.05),而与给药前相比,中药复方组和阳性药物组奶牛在停药1 d后子宫黏液及血清中TNF-α、IL-6、IL-1β的水平均显著降低(P<0.05);给药前后,中药复方组与阳性药物组奶牛血清生化指标无显著性变化。综上,中药复方可发挥明显的抗炎作用,有效防治奶牛子宫内膜炎,治疗效果同抗生素相当,且无毒副作用,为开发治疗奶牛子宫内膜炎的新药物提供理论依据。To explore the therapeutic effects and anti-inflammatory actions of traditional Chinese medicine compound on cow endometritis,this study selected 20 cows with endometritis.The diseased cows were randomly divided into 2 groups,with 10 cows in each group;namely the traditional Chinese medicine compound group and the positive drug group.The cows in the traditional Chinese medicine compound group were orally administered with 0.4 g/kg body weight of the traditional Chinese medicine compound each day for 5 consecutive days,and the cows in the positive drug group were intramuscularly injected with 0.04 mL/kg body weight of ceftiofur hydrochloride injection each day for 5 consecutive days.Meanwhile,10 healthy cows were selected as the healthy control group.The temperature changes and uterine secretion scores of the cows in each group were recorded before administration and 1 day after drug withdrawal to evaluate the healing effect of endome⁃tritis in the treated groups.Simultaneously,the inflammatory factors levels of tumor necrosis factor-alpha(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6)in the uterine mucus and serum,and biochemical parameters in the serum of the cows were measured to evalu⁃ate the anti-inflammatory effect and safety of the traditional Chinese medicine compound.The results showed that,before administration,and compared with the healthy control group,the temperature and uterine secretion scores of the cows in the Chinese medicine compound group and the positive drug group were both significantly increased(P<0.05).One day after drug withdrawal,in the Chinese medicine compound group and the positive drug group the temperature and uterine secretion scores were significantly reduced(P<0.05).One day after cessation of treatment,the cure rates of the traditional Chinese medicine compound group and the positive drug group were 70%and 60%,respective⁃ly;the effective rates for the two groups were 10%and 20%,respectively,and their total effective rates were both 80%.Additionally,before administratio

关 键 词：奶牛 子宫内膜炎 中药 炎症 

分 类 号：S857.2[农业科学—临床兽医学]