Diverse phenotype of Méenière’s disease associated with family history,thyroid disorder,migraine and associated disorders  

作　　者：Ilmari Pyykkö Vinay Jing Zou Artur Vetkas Vinaya Manchaiah 

机构地区：[1]Hearing and Balance Research Unit,Field of Otolaryngology,School of Medicine,Faculty of Medicine and Health Technology,Tampere University,Tampere,Finland [2]Audiology Group,Department of Neuromedicine and Movement Sciences,Norwegian University of Science and Technology,Trondheim,Norway [3]Department of Otolaryngology-Head and Neck Surgery,University of Colorado School of Medicine,Aurora,CO,USA [4]Department of Otolaryngology-Head and Neck Surgery,Center for Otolaryngology-Head&Neck Surgery of the Chinese PLA,Changhai Hospital,Second Military Medical University,Shanghai,China [5]Neurology Clinic,Department of Neurosurgery,Tartu University Hospital,Tartu,Estonia [6]UCHealth Hearing and Balance,University of Colorado Hospital,Aurora,CO,USA [7]Virtual Hearing Lab,Collaborative Initiative Between University of Colorado School of Medicine and University of Pretoria,Aurora,CO,USA [8]Department of Speech-Language Pathology and Audiology,University of Pretoria,Pretoria,South Africa [9]Department of Speech and Hearing,School of Allied Health Sciences,Manipal University,Manipal,Karnataka,India

出　　处：《Journal of Otology》2024年第4期185-192,共8页中华耳科学杂志（英文版）

摘　　要：Objective:To better understand the clinical phenotype of Méenière’s disease(MD),we examined family history,thyroid disorder,migraine,and associated disorders in complaints of people living with MD.Method:We designed the study as a retrospective and examined data gathered from 912 participants with MD.Their data were originally collected by the Finnish M′eni`ere Federation(FMF).The survey data included individual case histories for environmental factors,comorbidities,disease-specific complaints,impact-related questions,cognitive complaints,health-related quality of life(HRQoL),and sense of coherence(SOC).Results:We observed significant differences between those with and without sporadic occurrence,family history,thyroid disorder,and migraine-associated complaints.Family history explained 20%of variability in patient complaints.Patients with a family history of MD whose disease started at younger age experienced balance problems,more severe vertigo spells,more severe vestibular drop attacks(VDA),and less nausea,although they had good SOC.Thyroid disorder explained 14%of variability in patient complaints.MD patients with a thyroid disorder comorbidity suffered more often from constant dizziness,balance problems,greater impact of hearing problems,cognitive complaints,and poor HRQoL.Migraine explained 12%of variability in patients’complaints and was associated with poor SOC and cognitive balance problems.MD patients with both thyroid disorder and migraine used antidepressants more often than other groups.Logistic regression analysis showed comorbidities of ischemic brain disorder(among 7.1%),kidney insufficiency(among 1.2%),and diabetes(among 7.3%)had statistically significant but restricted association with balance and gait problems,VDA,and reduced HRQoL.Conclusions:Family history of MD and thyroid disorder or migraine comorbidities in MD influence the complaint pattern and partially explain complex symptom profiles,including symptoms of cognitive problems.Confounders play a minimal role in complaint profile

关 键 词：Méenière’s disease MIGRAINE THYROID Family history HEREDITARY 

分 类 号：R764.33[医药卫生—耳鼻咽喉科]