2022年菏泽市艾滋病患者CD4^(+)T淋巴细胞、病毒载量和耐药检测结果及其相关性分析  

Detection results and correlation analysis of CD4^(+)T lymphocytes,viral load and drug resistance of AIDS patients in Heze City in 2022

作　　者：雷霁 李一苇[1] 李晓寒[1] LEI Ji;LI Yiwei;LI Xiaohan(Clinical Laboratory,Heze Center for Disease Control and Prevention,Heze,Shandong 274000,China)

机构地区：[1]菏泽市疾病预防控制中心检验科,山东菏泽274000

出　　处：《职业与健康》2024年第19期2619-2622,共4页Occupation and Health

基　　金：山东省医药卫生科技发展计划(202112060725)。

摘　　要：目的分析2022年菏泽市艾滋病患者接受治疗后CD4^(+)T淋巴细胞、病毒载量和耐药检测结果的相关性,为艾滋病患者抗病毒的治疗效果提供依据。方法收集2022年菏泽市经抗病毒治疗后的艾滋病患者外周血1172份进行CD4^(+)T淋巴细胞计数检测,分离血浆后进行病毒载量和耐药检测,并对数据进行分析。结果抗病毒治疗后,787例(67.15%)患者CD4^(+)T淋巴细胞≥400个/μL,病毒抑制率[病毒载量(viral load,VL)<1000]达92.32%。不同病毒含量的艾滋病患者CD4^(+)T细胞计数构成呈负相关(r=-0.250,P<0.01)。耐药病例占抗病毒治疗失败病例的比例为44.44%,药物中耐药发生率较高的是奈韦拉平(nevirapine,NVP)、依菲韦伦(efavirenz,EFV)、恩曲他滨(emtricitabine,FTC)和拉米夫定(lamivudine,3TC)。结论2022年菏泽市抗病毒失败和耐药比例较低,联合应用外周血CD4^(+)T淋巴细胞检测和病毒载量检测能够较好指导抗病毒治疗效果。Objective To analyze the correlation between CD4^(+)T lymphocytes,viral load and drug resistance detection results of AIDS patients after antiviral therapy in Heze City in 2022,and provide basis for judging the efficacy of anti-viral therapy of AIDS patients.Methods A total of 1172 peripheral blood samples from AIDS patients in Heze City after antiviral therapy were collected for CD4^(+)T lymphocyte count detection.The plasma was separated and tested for viral load(VL)and drug resistance.The data were analyzed.Results After antiviral therapy,787 patients(67.15%)had CD4^(+)T lymphocytes≥400 cells/μL and the viral inhibition rate(VL<1000)reached 92.32%.The composition of CD4^(+)T cell count in AIDS patients with different viral content was negatively correlated(r=-0250,P<0.01).The proportion of drug-resistant cases in the failure of antiviral therapy was 44.44%,and the drugs with a higher incidence of resistance were nevirapine(NVP),efavirenz(EFV),emtricitabine(FTC)and lamivudine(3TC)Conclusion In 2022,the proportion of antiviral failure and drug resistance in Heze City is relatively low.The combination of peripheral blood CD4^(+)T lymphocyte detection and viral load detection can better guide the effectiveness of antiviral therapy.

关 键 词：艾滋病患者 CD4^(+)T淋巴细胞 病毒载量 耐药检测 

分 类 号：R512.91[医药卫生—内科学]