不同精液优化处理方式对夫精宫腔内人工授精临床妊娠结局的影响  

Effect of Different Semen Optimization Methods on Clinical Pregnancy Outcome of Intrauterine Insemination by AIH

作　　者：王娟[1] WANG Juan(Hunan People's Hospital(The First Affiliated Hospital of Hunan Normal University),Changsha Hunan 410002)

机构地区：[1]湖南省人民医院(湖南师范大学附属第一医院),湖南长沙410002

出　　处：《医学临床研究》2024年第11期1743-1745,1749,共4页Journal of Clinical Research

摘　　要：【目的】探讨不同精液优化处理方式对夫精宫腔内人工授精(IUI)临床结局的影响。【方法】选取2020年1月至2023年12月本院收治的124例夫精IUI患者,根据不同精液优化处理方式将其分为上游法组(n=40)和密度梯度离心法组(n=84),比较两组妊娠情况及妊娠结局。【结果】124例IUI患者,妊娠20例(16.13%)。上游法组临床妊娠7例(17.50%),密度梯度离心法组临床妊娠13例(15.48%),两组均无生化妊娠,两组患者临床妊娠情况比较,差异无统计学意义(P>0.05)。上游法组7例临床妊娠中活产2例(28.57%),流产5例(71.43%),其中胎停引起的流产4例,异位妊娠引起的流产1例;密度梯度离心法组13例临床妊娠中活产11例(84.62%),流产2例(15.38%),其中2例流产均为胎停引起的流产。密度梯度离心法组活产率显著高于上游法组,流产率显著低于上游法组,差异均有统计学意义(P<0.05)。【结论】上游法和密度梯度离心法优化处理精液,对夫精IUI妊娠率的影响无差异,密度梯度离心法活产率高于上游法,流产率低于上游法。进行夫精IUI时,应当根据患者的具体情况选择不同的精液优化处理方式。【Objective】To investigate the effect of different semen optimization methods on the clinical outcome of intrauterine insemination by AIH.【Methods】A total of 124 patients with IUI admitted to our hospital from January 2020 to December 2023 were selected and divided into the upstream group(n=40)and the density gradient centrifuge group(n=84)according to different semen optimization treatment methods.The pregnancy status and pregnancy outcome of the two groups were compared.【Results】Of 124 IUI patients,20 were pregnant(16.13%).There were 7 clinical pregnancies(17.50%)in the upstream group and 13 clinical pregnancies(15.48%)in the density gradient centrifuge group.There was no biochemical pregnancy between the two groups.There was no statistical significance in clinical pregnancy between the two groups(P>0.05).In the upstream group of 7 clinical pregnancies,there were 2 live births(28.57%)and 5 abortions(71.43%),including 4 abortions caused by fetal stop and 1 abortion caused by ectopic pregnancy.Among the 13 clinical pregnancies in the density gradient centrifuge group,11 cases(84.62%)of live births and 2 cases(15.38%)of miscarriages were caused by fetal stop.The live birth rate of the density gradient centrifugation group was significantly higher than that of the upstream group,and the abortion rate was significantly lower than that of the upstream group,with statistical significance(P<0.05).【Conclusion】There is no difference between upstream method and density gradient centrifugation method on the pregnancy rate of intrauterine insemination by AIH.The live birth rate of density gradient centrifugation method is higher than upstream method,and the abortion rate is lower than upstream method.When intrauterine insemination is performed,different semen optimization methods should be selected according to the specific conditions of patients.

关 键 词：授精 人工(丈夫供体) 精液 妊娠结局 

分 类 号：R714.13[医药卫生—妇产科学]