β-七叶皂苷钠在高血压脑出血患者神经内镜引导微创血肿清除术后的应用效果  

Therapeutic effect ofβ-sodium aescinate on patients after neuroendoscopic guided minimally invasive hematoma removal surgery for hypertensive intracerebral hemorrhage

作　　者：赵悦 徐宣乐 赵虎威 杨少伟 刘春莹 Zhao Yue;Xu Xuanle;Zhao Huwei;Yang Shaowei;Liu Chunying(Department of Neurosurgery,the First People’s Hospital of Xianyang,Xianyang 712000,China;Department of Pharmacy,the First People’s Hospital of Xianyang,Xianyang 712000,China)

机构地区：[1]咸阳市第一人民医院神经外科,咸阳712000 [2]咸阳市第一人民医院药学部,咸阳712000

出　　处：《中国实用医刊》2024年第20期95-98,共4页Chinese Journal of Practical Medicine

基　　金：2022年度咸阳市重点研发计划项目(S2022-ZDYF-SF-969)。

摘　　要：目的探讨β-七叶皂苷钠在高血压脑出血患者神经内镜引导微创血肿清除术后的应用效果。方法队列研究。抽取2021年8月至2023年10月于咸阳市第一人民医院神经外科行高血压脑出血神经内镜引导微创血肿清除术的78例患者为研究对象,按照随机数字表法分为对照组和观察组,每组39例。对照组采用依达拉奉治疗,观察组在对照组的治疗基础上加用β-七叶皂苷钠。比较两组治疗前后神经功能[美国国立卫生研究院卒中量表(NIHSS)评分]、脑水肿体积、炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素1β(IL-1β)、C反应蛋白(CRP)、白细胞介素6(IL-6)]水平、血管内皮功能[内皮细胞生长因子(VEGF)、一氧化氮(NO)、内皮素-1(ET-1)]。记录两组用药过程中不良反应发生情况。结果治疗后,观察组NIHSS评分、脑水肿体积均低于对照组(P均<0.05)。治疗后,观察组TNF-α、IL-1β、CRP、IL-6水平均低于对照组(P均<0.05)。治疗后,观察组NO水平高于对照组,VEGF、ET-1水平低于对照组(P<0.05)。两组用药过程中均未出现严重不良反应。结论高血压脑出血患者神经内镜引导微创血肿清除术后应用β-七叶皂苷钠,可有效减轻机体炎症反应,改善血管内皮功能,减小脑水肿体积,加快神经功能恢复。Objective To investigate the therapeutic effect ofβ-sodium aescinate on patients after neuroendoscopic guided minimally invasive hematoma removal surgery for hypertensive intracerebral hemorrhage.Methods Seventy-eight patients who underwent neuroendoscopic guided minimally invasive hematoma removal surgery for hypertensive intracerebral hemorrhage in the Department of Neurosurgery of the First People’s Hospital of Xianyang from August 2021 to October 2023 were selected for the cohort study.And they were divided into the control group and the observation group using a random number table method,with 39 cases in each group.The control group received treatment with edaravone,while the observation group receivedβ-sodium aescinate based on the treatment of the control group.The neurological function assessed by the American National Institutes of Health stroke scale(NIHSS)score,brain edema volume,levels of inflammatory factors including tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),C-reactive protein(CRP)and interleukin-6(IL-6),vascular endothelial function evaluated by vascular endothelial growth factor(VEGF),nitric oxide(NO)and endothelin-1(ET-1)were compared between the two groups before and after surgery.The incidences of adverse reactions during treatment of the two groups were compared.Results After treatment,the observation group had lower NIHSS score and lower brain edema volume compared with the control group(all P<0.05).After treatment,the levels of TNF-α,IL-1β,CRP and IL-6 in the observation group were lower than those in the control group(all P<0.05).After treatment,the observation group had higher level of NO,but had lower levels of VEGF and ET-1(P<0.05).No severe adverse reaction was found in either group during treatment.Conclusions Application ofβ-sodium aescinate after neuroendoscopic guided minimally invasive hematoma removal surgery for hypertensive intracerebral hemorrhage can effectively reduce the inflammatory response in patients,improve vascular endothelial function,reduce the

关 键 词：高血压脑出血 神经内镜引导微创血肿清除术 Β-七叶皂苷钠 血管内皮功能 脑水肿 

分 类 号：R651.12[医药卫生—外科学]