强筋壮骨方治疗肝肾亏虚型绝经后骨质疏松症的疗效  

作　　者：张志敬[1] 胡劲涛[1] 陈美君[1] 贾高永 沈俊枫 张亮[1] 周辉[1] 潘浩[1] 

机构地区：[1]浙江中医药大学附属杭州市中医院,310007

出　　处：《浙江临床医学》2024年第11期1646-1648,共3页Zhejiang Clinical Medical Journal

基　　金：浙江省中医药科技计划项目(2022ZA117)。

摘　　要：目的探讨强筋壮骨方对肝肾亏虚型绝经后骨质疏松症患者骨密度、骨代谢及平衡能力的影响。方法选取2022年6月至2023年6月接受治疗的60例绝经后骨质疏松症患者,随机分为对照组和观察组,每组30例。对照组接受碳酸钙D3咀嚼片+骨化三醇胶丸治疗;观察组则在此基础上增加强筋壮骨方治疗。收集两组患者治疗前后的骨密度、疼痛评分(VAS)、平衡能力(OLST)及骨代谢指标(血清CTX、BGP水平)并进行比较。结果治疗前,两组患者髋部骨密度无显著差异(P>0.05);治疗后,观察组髋部骨密度显著高于对照组(P<0.05)。治疗前,两组VAS评分无显著差异(P>0.05);治疗后,两组VAS评分均降低,且观察组VAS评分低于对照组(P<0.05)。治疗前,两组OLST时间无显著差异(P>0.05);治疗后,观察组OLST时间显著增加,且高于对照组(P<0.05)。治疗前,两组血清CTX、BGP水平无显著差异(P>0.05);治疗后,观察组血清CTX、BGP水平降低,且低于对照组(P<0.05)。结论强筋壮骨方能改善肝肾亏虚型PMOP患者异常骨代谢,提高骨密度和平衡能力,减轻疼痛症状。Objective To explore the effect of Qiangjin Zhuanggu prescription on bone mineral density(BMD),bone metabolism and balance ability in patients with postmenopausal osteoporosis(PMOP)of the liver and kidney deficiency type.Methods A total of 60 patients with PMOP from June 2022 to June 2023 were randomly divided into a control group and an observation group,with 30 patients in each group.The control group received treatment with calcium carbonate D3 chewable tablets and calcitriol capsules,while the observation group received the same treatment plus Qiangjin Zhuanggu prescription.The bone density,pain scores(VAS),balance ability(OLST),and bone metabolism indicators(serum CTX,BGP levels)of the two groups before and after treatment were collected and compared.Results There was no significant difference in hip BMD between the two groups before treatment(P>0.05).The hip bone density of the observation group was significantly higher than that of the control group after treatment(P<0.05).Before treatment,there was no significant difference in VAS scores between the two groups(P>0.05).After treatment,VAS scores in both groups decreased,and the observation group's VAS scores were lower than those of the control group(P<0.05).Before treatment,there was no significant difference in OLST times between the two groups(P>0.05).After treatment,the OLST times in the observation group significantly increased and were higher than those of the control group(P<0.05).Before treatment,there was no significant difference in serum CTX,BGP levels between the two groups(P>0.05).After treatment,the serum CTX,BGP levels in the observation group decreased and were lower than those of the control group(P<0.05).Conclusion Qiangjin zhuanggu prescription can improve abnormal bone metabolism,increase bone mineral density and balance ability.Qiangjin zhuanggu prescription can relieve pain in PMOP patients with deficiency of liver and kidney.

关 键 词：绝经后 骨质疏松症 肝肾亏虚 

分 类 号：R259[医药卫生—中西医结合]