玉屏风颗粒和糖皮质激素联合治疗对咳嗽变异性哮喘患儿气道功能的影响  

Effect of Yupingfeng granules combined with glucocorticoids on airway function in children with cough variant asthma

作　　者：陈桦 王毅 CHEN Hua;WANG Yi(Department of Pediatrics,Xi'an Gaoxin Hospital,Xi'an 710000,Shaanxi Province,China)

机构地区：[1]西安高新医院儿科,陕西西安710000

出　　处：《新乡医学院学报》2024年第12期1149-1154,共6页Journal of Xinxiang Medical University

摘　　要：目的探讨玉屏风颗粒联合糖皮质激素治疗对咳嗽变异性哮喘(CVA)患儿气道功能的影响。方法选择2020年6月至2023年6月西安高新医院儿科收治的83例CVA患儿为研究对象。按照抽签法将患儿分为对照组(n=42)和观察组(n=41),对照组患儿给予糖皮质激素雾化吸入治疗,观察组患儿在对照组基础上加用玉屏风颗粒进行治疗。比较2组患儿的临床疗效、炎症因子水平、气道功能、淋巴细胞亚群、儿童哮喘控制测试(C-ACT)评分;分别于治疗前、治疗后采用双抗体夹心酶联免疫吸附法检测2组患儿血清肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)水平;应用肺功能检测仪测定2组患儿呼气峰值流速预计值(PEFpred)、呼气峰值流速(PEF)、第一秒用力呼气容积占预计值百分比(FEV_(1)%pred)、第一秒用力呼气容积与用力肺活量的比值(FEV_(1)/FVC);采用流式细胞术检测2组患儿CD4^(+)、CD8^(+)T淋巴细胞水平,并计算CD4^(+)/CD8^(+)值。结果对照组和观察组患儿临床总有效率分别为73.81%(31/42)、95.12%(39/41),观察组患儿总有效率显著高于对照组(P<0.05)。治疗前,2组患儿TNF-α、CRP、IL-6水平比较差异无统计学意义(P>0.05);2组患儿治疗后TNF-α、CRP、IL-6水平显著低于治疗前(P<0.05);治疗后,观察组患儿TNF-α、CRP、IL-6水平显著低于对照组(P<0.05)。治疗前,2组患儿PEFpred、PEF、FEV_(1)占预计值%、FEV_(1)/FVC比较差异无统计学意义(P>0.05);2组患儿治疗后PEFpred、PEF、FEV_(1)占预计值%、FEV_(1)/FVC水平显著高于治疗前(P<0.05);治疗后,观察组患儿PEFpred、PEF、FEV_(1)占预计值%、FEV_(1)/FVC水平显著高于对照组(P<0.05)。治疗前,2组患儿CD4^(+)、CD8^(+)以及CD4^(+)/CD8^(+)水平比较差异无统计学意义(P>0.05);2组患儿治疗后CD4^(+)、CD4^(+)/CD8^(+)水平显著高于治疗前,CD8^(+)水平显著低于治疗前(P<0.05);治疗后,观察组患儿CD4^(+)、CD4^(+)/CD8^(+)水平显Objective To explore the impact of Yupingfeng granules combined with glucocorticoids on airway function in children with cough variant asthma(CVA).Methods Eighty-three children with CVA admitted to the Department of Pediatrics of Xi'an Gaoxin Hospital from June 2020 to June 2023 were selected as the research subjects.The children were divided into control group(n=42)and observation group(n=41)according to the lottery method.Children in the control group were given glucocorticoid inhalation treatment,while children in the observation group were given Yupingfeng granules additionally on the basis of treatment in the control group.Clinical outcomes,inflammatory factor levels,airway function,lymphocyte subsets,and childhood asthma control test(C-ACT)scores of patients between the two groups were compared.The levels of tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),and interleukin-6(IL-6)were measured by using the double-antibody sandwich enzyme-linked immunosorbent assay before and after the treatment,respectively.The peak expiratory flow predicted(PEFpred),peak expiratory flow(PEF),percentage of forced expiratory volume in one second in predicted value(FEV_(1)%pred),and forced expiratory volume in one second/forced vital capacity(FEV_(1)/FVC)of children in the two groups were determined by using a lung function detector.The levels of CD4-positive T-lymphocytes(CD4^(+))and CD8-positive T-lymphocytes(CD8^(+))in the two groups were detected by using flow cytometry,and the CD4^(+)/CD8^(+)ratio was calculated.Results The total clinical effective rates of children in the control group and the observation group were 73.81%(31/42)and 95.12%(39/42),respectively;and the total effective rate of children in the observation group was significantly higher than that in the control group(P<0.05).Before treatment,there was no statistically significant difference in the levels of TNF-α,CRP,and IL-6 of children between the two groups(P>0.05);the levels of TNF-α,CRP,and IL-6 of children in the two groups after treatment wer

关 键 词：玉屏风颗粒 糖皮质激素 咳嗽变异性哮喘 气道功能 

分 类 号：R725.6[医药卫生—儿科]