银连祛风汤联合依巴斯汀及氯雷他定对慢性荨麻疹患者症状积分及免疫功能的影响  

Effect of Yinlian Qufeng Decoction Combined with Ebastine and Loratadine on Symptom Score and Immune Function in Patients with Chronic Urticaria

作　　者：孙倩倩 SUN Qianqian(Department of Dermatology,Tai'an Traditional Chinese Medicine Hospital,Tai'an 271000,China)

机构地区：[1]泰安市中医医院皮肤科,山东泰安271000

出　　处：《反射疗法与康复医学》2024年第13期16-19,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨银连祛风汤联合依巴斯汀及氯雷他定治疗慢性荨麻疹(CU)的临床效果。方法选取2022年6月—2023年6月泰安市中医医院收治的72例CU患者为研究对象,按随机数字表法将其分为对照组和观察组,每组36例。对照组采用依巴斯汀及氯雷他定治疗,观察组在对照组基础上采用银连祛风汤治疗,两组均持续治疗8周。比较两组患者的临床疗效、症状积分、免疫功能、生活质量及不良反应发生情况。结果观察组的治疗总有效率为94.44%,高于对照组的77.78%,差异有统计学意义(P<0.05)。治疗后,观察组的风团大小、风团数量、瘙痒程度积分分别为(0.61±0.12)分、(0.58±0.11)分、(0.71±0.12)分,均低于对照组的(0.82±0.15)分、(0.79±0.13)分、(0.95±0.16)分,组间差异有统计学意义(P<0.05);观察组的CD4^(+)、CD4^(+)/CD8^(+)水平分别为(40.14±4.23)%、(1.78±0.29),均高于对照组的(36.05±4.07)%、(1.41±0.26),CD8^(+)水平为(22.56±2.14)%,低于对照组的(25.63±2.25)%,组间差异有统计学意义(P<0.05);观察组的世界卫生组织生活质量评定量表简表中生理、心理、社会关系、环境领域评分分别为(86.78±5.35)分、(87.41±5.32)分、(88.89±5.13)分、(89.63±4.82)分,均高于对照组的(80.47±5.24)分、(80.89±5.24)分、(81.05±5.11)分、(82.11±5.04)分,组间差异有统计学意义(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论银连祛风汤联合依巴斯汀及氯雷他定可提高CU的治疗效果,加快疾病症状消失,减轻免疫障碍,改善患者生活质量,安全可靠。Objective To investigate the clinical effect of Yinlian Qufeng Decoction combined with ebastine and loratadine in the treatment of chronic urticaria(CU).Methods A total of 72 patients with CU admitted to Tai'an Traditional Chinese Medicine Hospital from June 2022 to June 2023 were selected as the research objects and were divided into a control group and an observation group according to random number table method,with 36 cases in each group.The control group was treated with ebastine and loratadine,and the observation group was treated with Yinlian Qufeng Decoction on the basis of the control group,both groups were treated for 8 weeks.The clinical efficacy,symptom scores,immune function,quality of life and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 94.44%,which was higher than 77.78%of the control group,the difference was statistically significant(P<0.05).After treatment,the scores of air mass size,air mass quantity and pruritus degree in the observation group were(0.61±0.12)points,(0.58±0.11)points and(0.71±0.12)points,respectively,which were lower than(0.82±0.15)points,(0.79±0.13)points and(0.95±0.16)points in the control group,the differences between the groups were statistically significant(P<0.05);the CD4^(+),CD4^(+)/CD8^(+)levels in the observation group were(40.14±4.23)%and(1.78±0.29),respectively,which were higher than(36.05±4.07)%and(1.41±0.26)in the control group,and the CD8^(+)level was(22.56±2.14)%,which was lower than(25.63±2.25)%in the control group,and the differences between the groups were statistically significant(P<0.05);the scores in the physiological,psychological,social relationship and environmental domains of the World Health Organization quality of life-Brief Version scale in the observation group were(86.78±5.35)points,(87.41±5.32)points,(88.89±5.13)points and(89.63±4.82)points,respectively,which were higher than(80.47±5.24)points,(80.89±5.24)points,(81.05±5.11)points and(82.11±5.

关 键 词：慢性荨麻疹 银连祛风汤 依巴斯汀 氯雷他定 免疫功能 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]