基因转染猪皮在电弧烧伤患者中的舒适化疗效  

Comfort efficacy of gene-transfected pig skin in arc burn patients

作　　者：王倩 段雪敬 哈宏伟 赵宇辉 王桂玲 刘军 WANG Qian;DUAN Xuejing;HA Hongwei;ZHAO Yuhui;WANG Guiling;LIU Jun(First Department of Burn and Plastic Surgery,Tangshan Workers'Hospital,Tangshan,Hebei Province,063000,China;Burn Operating room,Tangshan Workers'Hospital,Tangshan,Hebei Province,063000,China)

机构地区：[1]唐山市工人医院烧伤整形一科,河北唐山063000 [2]唐山市工人医院烧伤手术室,河北唐山063000

出　　处：《陆军军医大学学报》2024年第23期2649-2654,共6页Journal of Army Medical University

基　　金：2021年度河北省医学科学研究课题计划(20210758)。

摘　　要：目的 观察基因转染猪皮在电弧烧伤创面中的舒适化疗效。方法 选择2020年6月-2022年12月在我院烧伤整形科治疗的56例电弧烧伤患者为研究对象,以随机数字表法将其分为治疗组和对照组,每组28例。2组患者电弧烧伤创面均给予清创治疗,包括去除创面的污染物、坏死的腐皮,并使用生理盐水进行创面清洁,清创后浅Ⅱ度烧伤患者对照组创面应用银离子功能性抗菌敷料覆盖,无菌棉垫包扎;治疗组应用解冻并软化后的基因转染猪皮覆盖。深Ⅱ度烧伤创面简单清创后用凡士林纱布覆盖,无菌棉垫包扎,待烧伤48 h后患者病情稳定,创面给予磨削痂治疗,磨削痂后对照组创面同样应用银离子功能性抗菌敷料覆盖,无菌棉垫包扎;治疗组创面同样给予解冻并软化后的基因转染猪皮覆盖。观察并对比2组患者疼痛视觉模拟评分(visual analogue scale,VAS)、状态焦虑量表(state anxiety inventory,SAI)评分、治疗过程满意度、患者舒适度以及创面愈合时间。结果 2组患者VAS评分与SAI评分在第1次换药时差异无统计学意义(P>0.05),但在第2次和第3次换药时,治疗组患者VAS评分与SAI评分均显著低于对照组(P<0.05);治疗组患者的舒适度显著高于对照组(P<0.05);治疗组患者创面愈合时间显著短于对照组(P<0.05)。结论 基因转染猪皮应用于电弧烧伤的创面疗效好,能够缩短创面愈合时间,降低换药疼痛,提高患者治疗的满意度、舒适度。Objective To observe the comfort effect of gene-transfected pig skin in patients with arc burn wound.Methods A total of 56 patients with electric arc burn treated in our hospital from June 2020 to December 2022 were enrolled and then randomly divided into treatment group and control group,with 28 cases in each group.Both groups were treated with debridement,including removing pollutants and necrotic skin,and cleaning the wounds with normal saline.After debridement,the shallow second-degree burn wounds in the control group were covered with silver ion functional antibacterial dressing and wrapped with sterile cotton pad,while those in the treatment group were covered with thawed and softened gene-transfected pig skins.For the deep second-degree burn wounds,after simple debridement,the wounds were treated with scab grinding in 48 h after burn when the condition of the patients was stable.After this,the wounds in the control group and the treatment group were treated as the shallow wounds,respectively.Visual Analogue Scale(VAS),State Anxiety Inventory(SAI) score,treatment process satisfaction,patient comfort and time for wound healing were observed and compared between the 2 groups.Results There was no significant difference in the VAS score and SAI score between the 2 groups at the first dressing change(P>0.05),but the VAS score and SAI score were obviously lower in the treatment group than the control group at the second and third dressing changes(P<0.05).The treatment group obtained notably better comfort level and shorter time for wound healing than the control group(P<0.05).Conclusion Gene-transfected pig skin shows good efficacy in the wound surface of arc burn,which can shorten the wound healing time,reduce the pain of dressing change and improve the satisfaction and comfort of patients.

关 键 词：基因转染猪皮 电弧烧伤 疼痛 愈合时间 舒适化 满意度 

分 类 号：R322.991[医药卫生—人体解剖和组织胚胎学] R622.1[医药卫生—基础医学] R647