代谢途径在中性粒细胞抗感染免疫过程中的作用  

Role of metabolic pathways in neutrophils in response to infection

作　　者：王晓璐 苏建玲 冯诗琪 何石萍 李洋[2] 

机构地区：[1]中山大学附属第八医院(深圳福田)综合(特需)一病区,深圳518033 [2]南方医科大学附属广东省人民医院(广东省医学科学院)风湿免疫科,广州510180

出　　处：《中华微生物学和免疫学杂志》2024年第11期965-969,共5页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金面上项目(82271822)。

摘　　要：中性粒细胞是抗感染免疫过程中快速识别和消除病原体的一线细胞,主要依靠糖酵解来发挥其杀伤功能。尽管关于影响中性粒细胞功能的代谢途径研究开始较早,但中性粒细胞在抗感染过程中如何进行代谢转变仍然知之甚少。目前,已证明糖原代谢对多种中性粒细胞的功能具有重要作用,除糖酵解以外的其他代谢途径,如线粒体相关代谢、中性粒细胞分化过程中的脂肪酸氧化,也对中性粒细胞功能的调控具有潜在贡献。本文综述了目前关于中性粒细胞抗感染反应过程中的代谢调节作用,旨在为中性粒细胞的代谢研究提供一定的理论参考。Neutrophils as the first immune responders to infection can quickly identify and eliminate pathogens.The mainly rely on glycolysis to exert their killing functions.Although researches on the metabolic shifs that affect neutrophil functions began early,little is known about how neutrophils undergo metabolic transformation during the anti-infection process.It has been proven that glycogen metabolism plays an important role in regulating the functions of neutrophils.Other metabolic pathways besides glycolysis,such as mitochondrial metabolism and fatty acid oxidation during neutrophil differentiation,have potential contributions to the regulation of neutrophils′functions.This review summaries current studies about metabolic regulatory effects of neutrophils on anti-infection responses,intending to provide reference for further study on the metabolism of neutrophils.

关 键 词：中性粒细胞 代谢途径 感染免疫 

分 类 号：R392[医药卫生—免疫学]