子宫内膜癌患者三维能量多普勒超声表现及与血清HE4、CDCA5、IGF-1的相关性  

Three-Dimensional Energy Doppler Ultrasound Manifestations and Correlation with Serum HE4, CDCA5,and IGF-1 in Patients with Endometrial Cancer

作　　者：蒋惠梅 JIANG Hui-mei(Department of Ultrasound,Pucheng County Maternal and Child Health Hospital,Fujian Nanping 353400)

机构地区：[1]浦城县妇幼保健院超声科,福建南平353400

出　　处：《中国医疗器械信息》2024年第22期131-133,共3页China Medical Device Information

摘　　要：目的:探讨子宫内膜癌患者三维能量多普勒超声表现及与血清生化指标的相关性。方法:选取2020年9月~2024年2月收治的子宫内膜癌患者53例为观察组,另选同期收治的良性子宫内膜病患者53例为对照组,两组患者均接受经阴道超声检查,采用三维能量多普勒模式进行扫描,以VOCAL软件包计算血管形成-血流指数(VFI)、血管形成指数(VI)、内膜容积(EV)、血流指数(FI)。采集两组血清样本,以酶联免疫吸附法测定人附睾蛋白4(HE4)、细胞分裂周期相关蛋白5(CDCA5)、胰岛素样生长因子1(IGF-1)水平。以Pearson相关系数分析子宫内膜癌患者VFI、VI、EV、FI与血清HE4、CDCA5、IGF-1的相关性。结果:观察组VFI、VI、EV、FI与对照组比较,均明显更高(P<0.05);观察组血清HE4、CDCA5、IGF-1水平与对照组比较,均明显更高(P<0.05);子宫内膜癌患者VFI、VI、EV、FI与血清HE4、CDCA5、IGF-1呈正相关(P<0.05)。结论:子宫内膜癌患者三维能量多普勒超声指标表现为血流灌注增加、子宫内膜增厚、新生血管形成,且与部分血清生化指标具有相关性。Objective:To investigate the three-dimensional power Doppler ultrasound manifestations and correlation with serum biochemical indicators in patients with endometrial cancer.Methods:53 patients with endometrial cancer admitted to our hospital from September 2020 to February 2024 were selected as the observation group,and selected 53 patients with benign endometrial disease admitted to our hospital during the same period as the control group.Both groups of patients received transvaginal ultrasound examination,and the three-dimensional energy Doppler mode was used for scanning.The VOCAL software package was used to calculate the vascular formation-blood flow index(VFI),vascular formation index(VI),endometrial volume(EV),and blood flow index(FI).Serum samples of the two groups were collected and the levels of human epididymal protein 4(HE4),cell division cycle associated protein 5(CDCA5)and insulin-like growth factor 1(IGF-1)were determined by enzyme-linked immunosorbent assay.The correlations of VFI,VI,EV and FI with serum HE4,CDCA5 and IGF-1 in patients with endometrial cancer were analyzed by Pearson correlation coefficient.Results:In observation group,the VFI,VI,EV and FI were compared with control group,significantly higher(P<0.05).In observation group,the serum HE4,CDCA5,IGF-1 levels were compared with control group,significantly higher(P<0.05).VFI,VI,EV and FI were positively correlated with serum HE4,CDCA5 and IGF-1 in endometrial carcinoma patients(P<0.05).Conclusion:In patients with endometrial cancer,three dimensional energy Doppler ultrasound showed increased blood perfusion,endometrial thickening,neovascularization,and it was correlated with some serum biochemical indexes.

关 键 词：子宫内膜癌 三维能量 多普勒超声 生化指标 相关性 

分 类 号：R445.1[医药卫生—影像医学与核医学]